2. Gene
  3. SLITRK5 - SLIT and NTRK like family member 5 Gene

SLITRK5 - SLIT and NTRK like family member 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SLIT 和 NTRK 样家族成员 5

种属: Homo sapiens

同用名: LRRC11; bA364G4.2

基因 ID: 26050 | 基因类型: protein coding

关于 SLITRK5

Cytogenetic location: 13q31.2 Genomic coordinates (GRCh38): 13:87,671,371-87,679,616 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 25 paralogues. Biased expression in brain (RPKM 5.9), thyroid (RPKM 2.1) and 4 other tissues.

功能概要

SLITRK 家族的成员，如 SLITRK5，是具有 2 个 N 末端富含亮氨酸重复序列 (LRR) 结构域的整合膜蛋白，类似于 SLIT 蛋白 (参见 SLIT1；MIM 603742) 。大多数 SLITRK，包括 SLITRK5，也有与神经营养蛋白受体共享同源性的 C 末端区域 (参见 NTRK1；MIM 191315) 。 SLITRK 主要在神经组织中表达并具有神经突调节活性 (Aruga 等人，2003 [PubMed 14557068]) 。[OMIM 提供，2008 年 3 月]

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]

SLITRK5 基因产物(3)

mRNA Protein Name
NM_001384609.1 NP_001371538.1 SLIT and NTRK-like protein 5 precursor
NM_001384610.1 NP_001371539.1 SLIT and NTRK-like protein 5 precursor
NM_015567.2 NP_056382.1 SLIT and NTRK-like protein 5 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in synaptic membrane adhesion IDA
IDA: 通过直接分析推断
23345436 GOA
involved in synaptic membrane adhesion IMP
IMP: 通过突变表型推断
23345436 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLITRK5 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (130 - 189)

LRR_1

LRR_1: Leucine Rich Repeat (202 - 217)

LRR_8

LRR_8: Leucine rich repeat (434 - 493)

LRR_8

LRR_8: Leucine rich repeat (505 - 563)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 958 a.a.
蛋白主名 其他名称

SLIT and NTRK-like protein 5

leucine rich repeat containing 11

SLITRK5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLITRK5 O94991 CLCNKA Homo sapiens P51800-3
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior
Trichotillomania

TTM

Hair-Pulling Syndrome

Compulsive Hair Plucking

Hair Pulling Disorder
Body Dysmorphic Disorder

Dysmorphophobia

Body Dysmorphia

Dysmorphic Syndrome

Body Dysmorphic Disorders
Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders
Tic Disorder

Tics

Behavioral Tic
Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet

Supratentorial Embryonal Tumor, Not Otherwise Specified

Ewings Sarcoma-Primitive Neuroectodermal Tumor
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13377 SLITRK5 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLITRK5 VGNC VGNC:34966
Macaca mulatta SLITRK5 VGNC VGNC:77743
Mus musculus SLITRK5 MGD MGI:2679448
Canis familiaris SLITRK5 VGNC VGNC:46510
Rattus norvegicus SLITRK5 RGD RGD:1310957
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