STEAP2 - STEAP2 metalloreductase Gene

中文名称：STEAP2 金属还原酶

种属: Homo sapiens

同用名: STMP; IPCA1; PUMPCn; STAMP1; PCANAP1

基因 ID: 261729 | 基因类型: protein coding

关于 STEAP2

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:90,211,740-90,243,408 (from NCBI)

This gene has 10 transcripts (splice variants), 195 orthologues and 4 paralogues. Biased expression in prostate (RPKM 47.3), gall bladder (RPKM 4.2) and 6 other tissues.

功能概要

该基因是 STEAP 家族的一员，编码一种多通道膜蛋白，定位于高尔基复合体、质膜和胞质溶胶中的囊泡管状结构。小鼠中高度相似的蛋白质具有铁还原酶和铜还原酶活性，并在体外刺激细胞摄取铁和铜。人类基因转录表达的增加与前列腺癌的进展有关。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate Cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

STEAP2 基因产物(6)

mRNA	Protein	Name
NM_001040665.2	NP_001035755.1	metalloreductase STEAP2 isoform a
NM_001040666.2	NP_001035756.1	metalloreductase STEAP2 isoform b
NM_001244944.2	NP_001231873.1	metalloreductase STEAP2 isoform a
NM_001244945.2	NP_001231874.1	metalloreductase STEAP2 isoform b
NM_001244946.2	NP_001231875.1	metalloreductase STEAP2 isoform c
NM_152999.4	NP_694544.2	metalloreductase STEAP2 isoform a

基因本体论

生物过程
细胞组分

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi to plasma membrane transport	IDA IDA: 通过直接分析推断	12095985	GOA
involved in endocytosis	IDA IDA: 通过直接分析推断	12095985	GOA
involved in regulated exocytosis	IDA IDA: 通过直接分析推断	12095985	GOA
involved in response to hormone	IDA IDA: 通过直接分析推断	12095985	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi membrane	IDA IDA: 通过直接分析推断	12095985	GOA
located in cytosol	IDA IDA: 通过直接分析推断	12095985	GOA
located in early endosome	IDA IDA: 通过直接分析推断	12095985	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	12095985	GOA
located in trans-Golgi network transport vesicle	IDA IDA: 通过直接分析推断	12095985	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STEAP2 蛋白结构

F420_oxidored

Ferric_reduct

0
100
200
300
400
490 a.a.

蛋白主名

其他名称

metalloreductase STEAP2

STEAP family member 2, metalloreductase

关联疾病

疾病名称

别名

Cardiomyopathy, Familial Hypertrophic, 11

Hypertrophic Cardiomyopathy 11	CMH11
Cardiomyopathy, Hypertrophic, 11	Cardiomyopathy Familial Hypertrophic 11
Cardiomyopathy, Familial Hypertrophic 11	Cardiomyopathy, Hypertrophic, Familial, Type 11

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-173639	AZD0516	Inhibitor	95.82%	否
HY-RS13907	STEAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21200	Steap2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27716	Steap2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P991503	Anti-STEAP2 Antibody	Inhibitor	99.65%	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	STEAP2	VGNC	VGNC:46897
Bos taurus	STEAP2	VGNC	VGNC:35379
Mus musculus	STEAP2	MGD	MGI:1921301
Macaca mulatta	STEAP2	VGNC	VGNC:77946
Rattus norvegicus	STEAP2	RGD	RGD:1307050
Felis catus	STEAP2	VGNC	VGNC:65768

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