2. Gene
  3. Ogt - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

Ogt - O-linked N-acetylglucosamine (GlcNAc) transferase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 26295 | 基因类型: protein coding

关于 Ogt

功能概要

Enables several functions, including identical protein binding activity; monosaccharide binding activity; and protein N-acetylglucosaminyltransferase activity. Involved in several processes, including intracellular distribution of mitochondria; negative regulation of protein targeting to membrane; and regulation of protein phosphorylation. Located in several cellular components, including euchromatin; neuronal cell body; and zymogen granule. Part of protein N-acetylglucosaminyltransferase complex. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Apr 2022]

Ogt 基因产物(2)

mRNA Protein Name
NM_001398715.1 NP_001385644.1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2
NM_017107.3 NP_058803.2 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
10542233 RGD
enables peptide binding IDA
IDA: 通过直接分析推断
10542233 RGD
enables protein O-acetylglucosaminyltransferase activity IDA
IDA: 通过直接分析推断
9083067 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12435728 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
24995978 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
1533623 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
21712532 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
15561949 RGD
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
19098112 RGD
involved in cellular response to toxic substance IEP
IEP: 通过表达模式推断
12054585 RGD
involved in forebrain development IEP
IEP: 通过表达模式推断
22928023 RGD
involved in glucosamine metabolic process IDA
IDA: 通过直接分析推断
12054585 RGD
involved in glucosamine metabolic process IMP
IMP: 通过突变表型推断
18539296 RGD
involved in intracellular distribution of mitochondria IMP
IMP: 通过突变表型推断
24995978 RGD
involved in negative regulation of cellular response to hypoxia IMP
IMP: 通过突变表型推断
18539296 RGD
involved in negative regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
21712532 RGD
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
21712532 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
21712532 RGD
involved in negative regulation of protein targeting to membrane IMP
IMP: 通过突变表型推断
21712532 RGD
involved in positive regulation of cell size IMP
IMP: 通过突变表型推断
23665912 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
20978008 RGD
involved in positive regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
16052526 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
20978008 RGD
involved in positive regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
21712532 RGD
involved in protein O-linked glycosylation IDA
IDA: 通过直接分析推断
9083067 RGD
involved in protein O-linked glycosylation IMP
IMP: 通过突变表型推断
24995978 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
12618343 RGD
is active in cerebellar granule cell to Purkinje cell synapse IDA
IDA: 通过直接分析推断
12618343 RGD
located in euchromatin IDA
IDA: 通过直接分析推断
10580430 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
12618343 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
22928023 RGD
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
12618343 RGD
is active in presynaptic cytosol IDA
IDA: 通过直接分析推断
12618343 RGD
part of protein N-acetylglucosaminyltransferase complex IDA
IDA: 通过直接分析推断
10542233 RGD
located in zymogen granule IDA
IDA: 通过直接分析推断
10580430 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

O linked N-acetylglucosamine transferase

O-GlcNAc transferase subunit p110

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

O-linked N-acetylglucosamine transferase 110 kDa subunit

Ogt 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Ogt P56558 Nrf1 Mus musculus Q9WU00
Anti Tag CoIP
26231763
种属间
Ogt P56558 Foxo4 Mus musculus Q9WVH3
Anti Tag CoIP
19932102
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119738 OSMI-1 Inhibitor 99.90% 否
HY-114361 OSMI-4 Inhibitor 99.69% 否
HY-112174 UDP-GlcNAc disodium 99.92% 否
HY-145934 UDP-GalNAz disodium Substrate 99.78% 否
HY-145934A UDP-GlcNAz disodium Substrate 99.74% 否
HY-136282 ST045849 Inhibitor 99.82% 否
HY-139793 UDP-glucosamine disodium 99.43% 否
HY-135784 OSMI-2 Inhibitor 98.73% 否
HY-101548 OGT-IN-1 Inhibitor 98.14% 否
HY-119738A (Rac)-OSMI-1 Inhibitor 96.51% 否
HY-148113 PG 34 98.0% 否
HY-135785 OSMI-3 Inhibitor 99.08% 否
HY-125278 OGT-IN-4 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ogt NCBI NCBI:8473
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