2. Gene
  3. Irak4 - interleukin-1 receptor-associated kinase 4 Gene

Irak4 - interleukin-1 receptor-associated kinase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白介素 1 受体相关激酶 4

种属: Mus musculus

同用名: IRAK-4; NY-REN-64; 8430405M07Rik; 9330209D03Rik

基因 ID: 266632 | 基因类型: protein coding

关于 Irak4

Chromosome 15: 94,441,524-94,479,696 forward strand.GRCm39:CM001008.3

This gene has 3 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 19 phenotypes. Ubiquitous expression in large intestine adult (RPKM 7.), colon adult (RPKM 5.3) and 25 other tissues.

功能概要

该基因编码的蛋白可启动白细胞介素 1 受体结合活性。作用于细胞因子介导的信号通路的上游或内部。预计位于细胞外空间。预计在细胞质中有活性；核;和质膜。在中枢神经系统中表达；背主动脉;泌尿生殖系统；肝;和视网膜。该基因的人类直系同源物与原发性免疫缺陷病有关。与人 IRAK4（白细胞介素 1 受体相关激酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables interleukin-1 receptor binding activity. Acts upstream of or within cytokine-mediated signaling pathway. Predicted to be located in extracellular space. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in central nervous system; dorsal aorta; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Irak4 基因产物(1)

mRNA Protein Name
NM_029926.5 NP_084202.2 interleukin-1 receptor-associated kinase 4

Irak4 蛋白结构

Death_IRAK4

Death_IRAK4: cd08793 (8 - 107)

STKc_IRAK4

STKc_IRAK4: cd14158 (169 - 456)

  • 0
  • 100
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  • 400
  • 459 a.a.
蛋白主名 其他名称

interleukin-1 receptor-associated kinase 4

相关产品

Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-19836 Zimlovisertib Inhibitor 99.71% Phase 2
HY-135317 Emavusertib Inhibitor 99.96% Phase 2
HY-145483 KT-474 Inhibitor 99.27% Phase 2
HY-139374 Zabedosertib Inhibitor 98.14% Phase 2
HY-109585 IRAK4-IN-7 Inhibitor 99.36% Phase 1
Pre-clinical Phase
生物活性分子 (41)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-147141 HS-276 Inhibitor 98.59% 否
HY-103017A JH-X-119-01 Inhibitor ≥98.0% 否
HY-129966 PROTAC IRAK4 degrader-1 Inhibitor 99.72% 否
HY-111101 AZ1495 Inhibitor 98.18% 否
HY-134911 HS-243 Inhibitor 99.88% 否
HY-18992 AS2444697 Inhibitor 99.12% 否
HY-153188 JNJ-1013 Degrader 99.80% 否
HY-123854 PF-06426779 Inhibitor 99.83% 否
HY-135382A PROTAC IRAK4 degrader-3 Inhibitor 97.22% 否
HY-153224 GLPG2534 Inhibitor 98.05% 否
HY-77048 IRAK-4 protein kinase inhibitor 2 Inhibitor 98.01% 否
HY-13278A IRAK inhibitor 4 (trans) Inhibitor 99.02% 否
HY-131903 HS271 Inhibitor 99.92% 否
HY-146112 IRAK4-IN-14 Inhibitor / 否
HY-135317B Emavusertib hydrochloride Inhibitor / 否
HY-143231 IRAK4-IN-8 Inhibitor / 否
HY-160487 KME-2780 Inhibitor / 否
HY-146072 IRAK4-IN-11 Inhibitor / 否
HY-148275 KTX-955 Inhibitor / 否
HY-148277 KTX-612 / 否
HY-150732 IRAK4-IN-18 Inhibitor / 否
HY-162359 BIO-7488 Inhibitor / 否
HY-150594 IRAK4-IN-17 Inhibitor / 否
HY-143485 IRAK4-IN-9 Inhibitor / 否
HY-123956 HG-12-6 Inhibitor / 否
HY-143486 IRAK4-IN-10 Inhibitor / 否
HY-139317 PROTAC IRAK4 degrader-6 Inhibitor / 否
HY-139315 PROTAC IRAK4 degrader-4 Inhibitor / 否
HY-149345 IRAK4-IN-24 Inhibitor / 否
HY-160654 IRAK4 modulator-1 Modulator / 否
HY-150733 IRAK4-IN-19 Inhibitor / 否
HY-139316 PROTAC IRAK4 degrader-5 Inhibitor / 否
HY-150735 IRAK4-IN-20 Inhibitor / 否
HY-146113 IRAK4-IN-15 Inhibitor / 否
HY-150593 IRAK4-IN-16 Inhibitor / 否
HY-148238 GNE-2256 Inhibitor / 否
HY-155574 IRAK4-IN-27 Inhibitor / 否
HY-146073 IRAK4-IN-12 Inhibitor / 否
HY-148276 KTX-497 / 否
HY-146111 IRAK4-IN-13 Inhibitor / 否
HY-135382 PROTAC IRAK4 degrader-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Irak4 NCBI NCBI:51135
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