2. PROTAC Immunology/Inflammation
  3. PROTACs IRAK Toll-like Receptor (TLR) Interleukin Related
  4. PROTAC IRAK4 degrader-13

PROTAC IRAK4 degrader-13 (Degrader 1) 是一种选择性 IRAK4 PROTAC 降解剂，对 PBMCs 中的单核细胞和淋巴细胞的 DC50 分别为 0.86 nM 和 1.1 nM。PROTAC IRAK4 degrader-13 显著诱导 TIR 信号激活，并抑制 Imiquimod (HY-B0180) 诱发的银屑病小鼠模型中循环促炎细胞因子的表达。PROTAC IRAK4 degrader-13 可用于 TLR- 和 IL-1R 驱动的中性粒细胞炎症疾病，如化脓性汗腺炎 (HS) 和特应性皮炎 (AD) 的研究。粉色：IRAK4 ligand；蓝色：E3 ligase ligand；黑色：linker

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PROTAC IRAK4 degrader-13

PROTAC IRAK4 degrader-13 Chemical Structure

CAS No. : 2432992-21-5

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PROTAC IRAK4 degrader-13 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 IRAK 亚型特异性产品:

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IRAK1 IRAK4

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC IRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader with DC50s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod (HY-B0180) induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR- and IL-1R-driven driven neutrophilic inflammation diseases like hidradenitis suppurativa (HS) and atopic dermatitis (AD) research[1]. Pink: IRAK4 ligand; Blue: E3 ligase ligand; Black: linker

IC50 & Target[1]

IRAK4

 

IL-6

 

IL-8

 

IL-17

 

IL-22

 

IL-23

 

IL-1b

 

分子量

843.94

Formula

C44H52F3N9O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC IRAK4 degrader-13 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC IRAK4 degrader-132432992-21-5PROTACsIRAKToll-like Receptor (TLR)Interleukin RelatedInterleukin-1 receptor associated kinaseIL-1R associated kinaseILPROTACDegradationIRAK4TIR signalPBMCPsoriasis mice modelNeutrophilic inflammation diseasesHidradenitis suppurativaHSAtopic dermatitisADInhibitorinhibitorinhibit

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产品名称：
PROTAC IRAK4 degrader-13
目录号：
HY-175022
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