2. Gene
  3. Nlrc3 - NLR family, CARD domain containing 3 Gene

Nlrc3 - NLR family, CARD domain containing 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CLR16.2; mFLJ00348; D230007K08Rik

基因 ID: 268857 | 基因类型: protein coding

关于 Nlrc3

功能概要

Enables phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of cytokine production; and negative regulation of defense response. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling; regulation of protein ubiquitination; and response to lipopolysaccharide. Predicted to be located in centriolar satellite; intracellular membrane-bounded organelle; and perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human NLRC3 (NLR family CARD domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlrc3 基因产物(2)

mRNA Protein Name
NM_001081280.2 NP_001074749.1 protein NLRC3 isoform 1
NM_175547.4 NP_780756.1 protein NLRC3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular function inhibitor activity IDA
IDA: 通过直接分析推断
22863753 MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding IDA
IDA: 通过直接分析推断
27951586 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22863753 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
22863753 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
22863753 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IGI
IGI: 通过遗传相互作用推断
22863753 MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
22863753 MGI
involved in negative regulation of cytokine production involved in inflammatory response IMP
IMP: 通过突变表型推断
24560620 MGI
involved in negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
27951586 MGI
involved in negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
27951586 MGI
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
24560620 MGI
involved in negative regulation of innate immune response IMP
IMP: 通过突变表型推断
24560620 MGI
involved in negative regulation of interferon-alpha production IMP
IMP: 通过突变表型推断
24560620 MGI
involved in negative regulation of interferon-beta production IMP
IMP: 通过突变表型推断
24560620 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
22863753 MGI
involved in negative regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
22863753 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
22863753 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
27951586 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
22863753 MGI
acts upstream of or within regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
22863753 MGI
acts upstream of or within regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
22863753 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
22863753 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein NLRC3

caterpillar 16.2

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0921 Dihydromethysticin 99.94% 否
HY-RS09346 NLRC3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20066 Nlrc3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26570 Nlrc3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nlrc3 NCBI NCBI:197358
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