2. Gene
  3. Nlrc4 - NLR family, CARD domain containing 4 Gene

Nlrc4 - NLR family, CARD domain containing 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; Card12; 9530011P19Rik

基因 ID: 268973 | 基因类型: protein coding

关于 Nlrc4

功能概要

Enables identical protein binding activity. Involved in several processes, including positive regulation of interleukin-1 beta production; protein homooligomerization; and response to bacterium. Acts upstream of or within regulation of apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol. Part of IPAF inflammasome complex. Used to study familial cold autoinflammatory syndrome 4. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 4. Orthologous to human NLRC4 (NLR family CARD domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]

Nlrc4 基因产物(1)

mRNA Protein Name
NM_001033367.3 NP_001028539.1 NLR family CARD domain-containing protein 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
26449474 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22885697 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of innate immune response IMP
IMP: 通过突变表型推断
16648852 MGI
involved in defense response to bacterium IMP
IMP: 通过突变表型推断
16648852 MGI
involved in detection of bacterium IMP
IMP: 通过突变表型推断
22885697 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
15190255 MGI
involved in inflammatory response IMP
IMP: 通过突变表型推断
16648852 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
16648852 MGI
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
21874021 MGI
involved in pyroptotic inflammatory response IMP
IMP: 通过突变表型推断
16648852 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: 通过突变表型推断
15190255 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
15190255 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of IPAF inflammasome complex IDA
IDA: 通过直接分析推断
21874021 MGI
located in cytosol IDA
IDA: 通过直接分析推断
22885697 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

NLR family CARD domain-containing protein 4

caspase recruitment domain family, member 12

caspase recruitment domain-containing protein 12

ice protease-activating factor

Nlrc4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nlrc4 Q3UP24 Naip5 Mus musculus Q9R016
Pull Down
26449474
种属内
Nlrc4 Q3UP24 Naip5 Mus musculus Q9R016
Anti Tag CoIP
26449474
种属内
Nlrc4 Q3UP24 Naip5 Mus musculus Q9R016
GMS
23765277
种属内
Nlrc4 Q3UP24 Casp1 Mus musculus P29452
Anti Tag CoIP
22885697
种属内
Nlrc4 Q3UP24 Casp1 Mus musculus P29452
FPS
26449474
种属间: 跨种属相互作用 种属内: 同种属相互作用

Nlrc4 抗体

目录号 产品名 应用 反应物种
HY-P84624 phospho-NLRC4(Ser-533) Antibody (YA4321) WB, ICC/IF, ELISA Human, Mouse
HY-P84625 phospho-NLRC4(Ser-533) Antibody (YA4322) ICC/IF, FC, ELISA Human

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N1939 Icariside I 99.30% 否
HY-152670 JC2-11 Inhibitor 98.03% 否
HY-148258 GDC-2394 Inhibitor 99.87% 否
HY-150206 NLRP3-IN-13 Inhibitor 98.03% 否
HY-RS09347 NLRC4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-161669 NLRP3-IN-40 Inhibitor / 否
HY-170233 NLRP3-IN-75 Inhibitor / 否
HY-175814 NLRP3-IN-83 Inhibitor / 否
HY-RS17988 Nlrc4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24459 Nlrc4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nlrc4 NCBI NCBI:58484
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