2. Gene
  3. Afdn - afadin, adherens junction formation factor Gene

Afdn - afadin, adherens junction formation factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Af6; Mllt4

基因 ID: 26955 | 基因类型: protein coding

关于 Afdn

功能概要

Enables LIM domain binding activity. Involved in dendrite arborization; positive regulation of mini excitatory postsynaptic potential; and regulation of cell morphogenesis. Located in adherens junction; axon; and somatodendritic compartment. Colocalizes with excitatory synapse. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]

Afdn 基因产物(1)

mRNA Protein Name
NM_013217.3 NP_037349.1 afadin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables LIM domain binding IPI
IPI: 通过物理相互作用推断
15140894 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10974003 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dendrite arborization IMP
IMP: 通过突变表型推断
22948147 RGD
involved in positive regulation of dendrite extension IMP
IMP: 通过突变表型推断
22948147 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
22948147 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
22948147 RGD
involved in positive regulation of mini excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
22948147 RGD
involved in postsynaptic specialization organization IDA
IDA: 通过直接分析推断
36803960 RGD
involved in postsynaptic specialization organization IMP
IMP: 通过突变表型推断
36803960 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
9334353 RGD
located in axon IDA
IDA: 通过直接分析推断
18181141 RGD
located in excitatory synapse IDA
IDA: 通过直接分析推断
22948147 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
36803960 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
36803960 RGD
located in somatodendritic compartment IDA
IDA: 通过直接分析推断
18181141 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

afadin

myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

translocated to, 4

myeloid/lymp

Afdn 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Afdn O35889 DBN1 Homo sapiens Q16643
Pull Down
23750010
种属间
Afdn O35889 DBN1 Homo sapiens Q16643
Anti Tag CoIP
23750010
种属间
Afdn O35889 DBN1 Homo sapiens Q16643
FRAP
23750010
种属间
Afdn O35889 Ctnna1 Mus musculus P26231
Pull Down
10974003
种属间
Afdn O35889 Ctnna1 Mus musculus P26231
Y2H
10974003
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00427 AFDN Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Afdn NCBI NCBI:4301
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