2. Gene
  3. LAMP3 - lysosomal associated membrane protein 3 Gene

LAMP3 - lysosomal associated membrane protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶酶体相关膜蛋白 3

种属: Homo sapiens

同用名: LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP

基因 ID: 27074 | 基因类型: protein coding

关于 LAMP3

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,122,215-183,163,813 (from NCBI)

This gene has 5 transcripts (splice variants) and 50 orthologues. Biased expression in lung (RPKM 74.1), appendix (RPKM 11.0) and 3 other tissues.

功能概要

树突状细胞 (DC) 是最有效的抗原呈递细胞。未成熟的 DC 有效地捕获抗原并分化成淋巴组织中的指状树突状细胞 (IDC) ，从而诱导初级 T 细胞反应 (de Saint-Vis 等人总结，1998 [PubMed 9768752]) 。[OMIM 提供，2010 年 12 月]

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

LAMP3 基因产物(1)

mRNA Protein Name
NM_014398.4 NP_055213.2 lysosome-associated membrane glycoprotein 3 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
25681212 GOA
involved in negative regulation of proteasomal protein catabolic process IMP
IMP: 通过突变表型推断
25681212 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
23651994 GOA
involved in regulation of autophagy IMP
IMP: 通过突变表型推断
25681212 GOA
involved in regulation of viral life cycle IMP
IMP: 通过突变表型推断
21810281 GOA
involved in response to interferon-alpha IMP
IMP: 通过突变表型推断
23651994 GOA
NOT involved in symbiont entry into host cell IMP
IMP: 通过突变表型推断
21810281 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
21810281 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
25681212 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21810281 GOA
located in vesicle IDA
IDA: 通过直接分析推断
25681212 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LAMP3 蛋白结构

Lamp

Lamp: Lysosome-associated membrane glycoprotein (Lamp) (120 - 416)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

lysosome-associated membrane glycoprotein 3

DC-lysosome-associated membrane glycoprotein

重组 LAMP3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77435 LAMP3/CD208 Protein, Human (HEK293, His) Q9UQV4/NP_055213.2 (K28-T381) ≥95%

关联疾病

疾病名称 别名
Mumps

Parotitis Due To Mumps Virus

Mumps Nos

Epidemic Parotitis

Infectious Parotitis
Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder

Rem Sleep Behaviour Disorder

Rapid Eye Movement Sleep Behaviour Disorder

Rem - [Rapid Eye Movement] Behaviour Disorder
Gaucher'S Disease

Gaucher Disease

Kerasin Thesaurismosis

Glucocerebrosidase Deficiency

Glucosylceramidase Deficiency

Cerebroside Lipidosis Syndrome

Acid Beta-Glucosidase Deficiency

Glucosylceramide Beta-Glucosidase Deficiency

Acute Cerebral Gaucher Disease

Gaucher Splenomegaly

Glucocerebrosidosis

Glucosyl Cerebroside Lipidosis

Kerasin Lipoidosis

Lipoid Histiocytosis

Glocucerebrosidase Deficiency

Sphingolipidosis 1

Gaucher Syndrome

Gauchers Disease

Gd

Glucosylceramide Lipidosis

Kerasin Histiocytosis

Gaucher Disease, Type 1

Gaucher Disease, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07511 LAMP3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17768 Lamp3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24235 Lamp3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus LAMP3 VGNC VGNC:30777
Rattus norvegicus LAMP3 RGD RGD:1307928
Felis catus LAMP3 VGNC VGNC:63187
Macaca mulatta LAMP3 VGNC VGNC:74045
Mus musculus LAMP3 MGD MGI:2441659
Others LAMP3 NCBI
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