CRCP - CGRP receptor component Gene

中文名称：CGRP 受体成分

种属: Homo sapiens

同用名: C17; RCP; RCP9; RPC9; POLR3I; POLR3J; CGRPRCP; CGRP-RCP

基因 ID: 27297 | 基因类型: protein coding

关于 CRCP

Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38): 7:66,114,818-66,154,568 (from NCBI)

This gene has 7 transcripts (splice variants) and 188 orthologues. Ubiquitous expression in bone marrow (RPKM 11.5), thyroid (RPKM 11.3) and 25 other tissues.

功能概要

该基因编码一种膜蛋白，该蛋白作为一种小神经肽受体复合物的一部分，可增加细胞内 cAMP 水平。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

CRCP 基因产物(5)

mRNA	Protein	Name
NM_001040648.2	NP_001035738.1	DNA-directed RNA polymerase III subunit RPC9 isoform c
NR_024548.2
NM_001040647.2	NP_001035737.1	DNA-directed RNA polymerase III subunit RPC9 isoform b
NM_014478.5	NP_055293.1	DNA-directed RNA polymerase III subunit RPC9 isoform a
NM_001142414.1	NP_001135886.1	DNA-directed RNA polymerase III subunit RPC9 isoform d

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-directed 5'-3' RNA polymerase activity	IDA IDA: 通过直接分析推断	12482973	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in transcription by RNA polymerase III	IDA IDA: 通过直接分析推断	12482973	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of DNA polymerase III complex	IDA IDA: 通过直接分析推断	12482973	GOA
part of RNA polymerase III complex	IDA IDA: 通过直接分析推断	33335104	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRCP 蛋白结构

RNA_pol_Rpb4

0
100
148 a.a.

蛋白主名

其他名称

DNA-directed RNA polymerase III subunit RPC9

CGRP-receptor component protein	RNA polymerase III subunit C9
calcitonin gene-related peptide-receptor component protein

CRCP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CRCP	O75575	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Prey Pooling	25416956
种属内	CRCP	O75575	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
种属内	CRCP	O75575	TCF12	Homo sapiens	Q99081	Y2H Array	25416956
种属内	CRCP	O75575	ZMIZ2	Homo sapiens	Q8NF64	Y2H Prey Pooling	25416956
种属内	CRCP	O75575	ZMIZ2	Homo sapiens	Q8NF64	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

CRCP 抗体

目录号	产品名	应用	反应物种
HY-P83605	CRCP Antibody (YA3350)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Intracranial Hypertension

Raised Intracranial Pressure

Communicating Hydrocephalus

Acquired Communicating Hydrocephalus

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Overhydrated Hereditary Stomatocytosis

Ohs	Potassium Sodium Disorder Of Erythrocyte
OHST	Stomatocytosis I
Potassium-Sodium Disorder Of Erythrocyte	Stomatocytosisiohst
Hereditary, Overhydrated, Cation-Leak Stomatocytosis	Overhydrated Cation Leak Stomatocytosis
Stomatocytosis, Overhydrated Hereditary

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03144	CRCP Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS03145	Crcp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS03146	Crcp Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CRCP	VGNC	VGNC:39594
Felis catus	CRCP	VGNC	VGNC:61163
Bos taurus	CRCP	VGNC	VGNC:27691
Mus musculus	CRCP	MGD	MGI:1100818
Macaca mulatta	CRCP	VGNC	VGNC:71432
Rattus norvegicus	CRCP	RGD	RGD:620753

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