2. Gene
  3. SGSM3 - small G protein signaling modulator 3 Gene

SGSM3 - small G protein signaling modulator 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：小 G 蛋白信号调节因子 3

种属: Homo sapiens

同用名: MAP; CIP85; RUSC3; RUTBC3; RABGAP5; RabGAP-5; rabGAPLP

基因 ID: 27352 | 基因类型: protein coding

关于 SGSM3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:40,370,594-40,410,289 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 45 paralogues. Ubiquitous expression in stomach (RPKM 33.5), prostate (RPKM 23.3) and 25 other tissues.

功能概要

启用 GTPase 激活剂活性和小 GTPase 结合活性。参与多个过程，包括 Rap 蛋白信号转导； GTP 酶活性的正调节； Rab 蛋白信号转导的调控。位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including Rap protein signal transduction; positive regulation of GTPase activity; and regulation of Rab protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SGSM3 基因产物(12)

mRNA Protein Name
NM_001301849.2 NP_001288778.1 small G protein signaling modulator 3 isoform 2
NM_001350039.2 NP_001336968.1 small G protein signaling modulator 3 isoform 3
NM_001350040.2 NP_001336969.1 small G protein signaling modulator 3 isoform 4
NM_001350041.2 NP_001336970.1 small G protein signaling modulator 3 isoform 5
NM_001350042.2 NP_001336971.1 small G protein signaling modulator 3 isoform 6
NM_001350043.2 NP_001336972.1 small G protein signaling modulator 3 isoform 7
NM_001350044.2 NP_001336973.1 small G protein signaling modulator 3 isoform 8
NM_001350045.2 NP_001336974.1 small G protein signaling modulator 3 isoform 8
NM_001350046.2 NP_001336975.1 small G protein signaling modulator 3 isoform 9
NM_001350047.2 NP_001336976.1 small G protein signaling modulator 3 isoform 10
NM_001350048.2 NP_001336977.1 small G protein signaling modulator 3 isoform 11
NM_015705.6 NP_056520.2 small G protein signaling modulator 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
17562788 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17509819 GOA
enables small GTPase binding IDA
IDA: 通过直接分析推断
17509819 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
17562788 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Rap protein signal transduction IEP
IEP: 通过表达模式推断
17509819 GOA
involved in plasma membrane to endosome transport IMP
IMP: 通过突变表型推断
17562788 GOA
involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
17562788 GOA
involved in regulation of Rab protein signal transduction IEP
IEP: 通过表达模式推断
17509819 GOA
NOT involved in regulation of cilium assembly IMP
IMP: 通过突变表型推断
17646400 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
17562788 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SGSM3 蛋白结构

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (119 - 324)

SH3_1

SH3_1: SH3 domain (486 - 531)

RUN

RUN: RUN domain (563 - 716)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
蛋白主名 其他名称

small G protein signaling modulator 3

RUN and SH3 containing 3

SGSM3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SGSM3 Q96HU1 LEMD2 Homo sapiens Q8NC56
Anti Tag CoIP
33961781
种属内
SGSM3 Q96HU1 LEMD2 Homo sapiens Q8NC56
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Perianal Hematoma

External Thrombosed Haemorrhoids

Thrombosed External Hemorrhoids
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12815 SGSM3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SGSM3 VGNC VGNC:108035
Canis familiaris SGSM3 VGNC VGNC:46106
Rattus norvegicus SGSM3 RGD RGD:735113
Mus musculus SGSM3 MGD MGI:1916329
Bos taurus SGSM3 VGNC VGNC:34552
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