POLM - DNA polymerase mu Gene

中文名称：DNA 聚合酶μ

种属: Homo sapiens

同用名: Tdt-N; Pol Mu

基因 ID: 27434 | 基因类型: protein coding

关于 POLM

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,072,062-44,082,530 (from NCBI)

This gene has 18 transcripts (splice variants), 185 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 6.9), lymph node (RPKM 5.6) and 25 other tissues.

功能概要

预测可实现 DNA 指导的 DNA 聚合酶活性。预计通过非同源末端连接参与双链断裂修复。预计在免疫球蛋白基因的 B 细胞分化和体细胞超突变的上游或内部起作用。预测位于核质中。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-directed DNA Polymerase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within B cell differentiation and somatic hypermutation of immunoglobulin genes. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

POLM 基因产物(4)

mRNA	Protein	Name
NM_001284330.2	NP_001271259.1	DNA-directed DNA/RNA polymerase mu isoform 2
NM_001284331.2	NP_001271260.1	DNA-directed DNA/RNA polymerase mu isoform 3
NM_001362683.2	NP_001349612.1	DNA-directed DNA/RNA polymerase mu isoform 4
NM_013284.4	NP_037416.1	DNA-directed DNA/RNA polymerase mu isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	22458338	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLM 蛋白结构

HHH_8

DNA_pol_lambd_f

DNA_pol_B_palm

DNA_pol_B_thumb

0
100
200
300
400
494 a.a.

蛋白主名

其他名称

DNA-directed DNA/RNA polymerase mu

Pol iota

POLM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	POLM	Q9NP87	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338
种属间	POLM	Q9NP87	tax	Human T-cell leukemia virus 1	P14079	Y2H Pooling	22458338

种属间: 跨种属相互作用 种属内: 同种属相互作用

POLM 抗体

目录号	产品名	应用	反应物种
HY-P86846	DNA polymerase mu Antibody (YA6539)	WB	Human

关联疾病

疾病名称

别名

Nemaline Myopathy 3

Nemaline Myopathy 3, Autosomal Dominant Or Recessive	Congenital Myopathy With Excess Of Thin Filaments
NEM3	Myopathy, Actin, Congenital, With Cores
Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments	Actin-Accumulation Myopathy
Actin Myopathy	Actin Accumulation Myopathy
Actin Filament Aggregate Myopathy	Nemaline Myopathy, Type 3
MPCETM	Acta1-Related Nemaline Myopathy
Actin Myopathy Congenital With Cores	Nemaline Myopathy 3 With Intranuclear Rods
Myopathy, Nemaline, Type 3

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Lig4 Syndrome

Dna Ligase Iv Deficiency	Ligase 4 Syndrome
LIG4S

Lung Adenoma

Adenoma Of Lung

Pulmonary Adenoma

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10834	POLM Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	POLM	VGNC	VGNC:33128
Mus musculus	POLM	MGD	MGI:1860191
Rattus norvegicus	POLM	RGD	RGD:1308247
Macaca mulatta	POLM	VGNC	VGNC:81742
Felis catus	POLM	VGNC	VGNC:68945
Canis familiaris	POLM	VGNC	VGNC:103698

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POLM - DNA polymerase mu Gene

关于 POLM

功能概要

POLM 基因产物(4)

POLM 蛋白结构

POLM 蛋白互作信息

POLM 抗体

关联疾病

直系同源

热门区域

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POLM - DNA polymerase mu Gene

关于 POLM

功能概要

POLM 基因产物(4)

POLM 蛋白结构

POLM 蛋白互作信息

POLM 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z