GLUD2 - glutamate dehydrogenase 2 Gene

中文名称：谷氨酸脱氢酶 2

种属: Homo sapiens

同用名: GDH2; GLUDP1

基因 ID: 2747 | 基因类型: protein coding

关于 GLUD2

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:121,047,610-121,050,094 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 285 orthologues, 1 paralogue and is associated with 1 phenotype.

功能概要

由该基因编码的蛋白质定位于线粒体，并作为同源六聚体在神经传递过程中回收谷氨酸。所编码的酶催化谷氨酸向α-酮戊二酸的可逆氧化脱氨作用。该基因是无内含子的。[RefSeq 提供，2010 年 1 月]

The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]

GLUD2 基因产物(1)

mRNA	Protein	Name
NM_012084.4	NP_036216.2	glutamate dehydrogenase 2, mitochondrial precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ADP binding	IDA IDA: 通过直接分析推断	12742085	GOA
enables GTP binding	IDA IDA: 通过直接分析推断	11032875	GOA
enables L-leucine binding	IDA IDA: 通过直接分析推断	12742085	GOA
enables glutamate dehydrogenase (NAD+) activity	IDA IDA: 通过直接分析推断	8207021	GOA
enables glutamate dehydrogenase [NAD(P)+] activity	IDA IDA: 通过直接分析推断	11032875	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in glutamate biosynthetic process	IDA IDA: 通过直接分析推断	11032875	GOA
involved in glutamate catabolic process	IDA IDA: 通过直接分析推断	11032875	GOA
involved in glutamate metabolic process	IDA IDA: 通过直接分析推断	8207021	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
NOT located in cytosol	IDA IDA: 通过直接分析推断	18688271	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	18688271	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLUD2 蛋白结构

ELFV_dehydrog_N

ELFV_dehydrog

0
100
200
300
400
500
558 a.a.

蛋白主名

其他名称

glutamate dehydrogenase 2, mitochondrial

GDH 2

GLUD2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GLUD2	P49448	GLUD1	Homo sapiens	P00367	Anti Tag CoIP	33961781
种属内	GLUD2	P49448	GLUD1	Homo sapiens	P00367	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Hereditary Late-Onset Parkinson Disease

Autosomal Dominant Late-Onset Parkinson Disease	Lopd
Hereditary Late Onset Parkinson Disease

Depersonalization Disorder

Neurotic Derealization	Depersonalization
Depersonalization/Derealization Disorder	Depersonalisation-Derealization Syndrome
Depersonalisation Disorder	Depersonalisation Neurosis
Depersonalisation Syndrome	Feeling Of Unreality
Feels Own Self Is Unreal	Neurotic State With Depersonalisation
Neurotic State With Depersonalization Episode

Hyperinsulinemic Hypoglycemia, Familial, 6

Hyperinsulinism-Hyperammonemia Syndrome	HHF6
Familial Hyperinsulinemic Hypoglycemia 6	Hi/Ha Syndrome
Ha/Hi Syndrome	Hyperinsulinemic Hypoglycemia Familial 6
Hyperinsulinism Hyperammonemia Syndrome	Hhs

Spastic Paraplegia 34, X-Linked

SPG34	Hereditary Spastic Paraplegia 34
X-Linked Spastic Paraplegia Type 34	X-Linked Spastic Paraplegia 34

Glioblastoma Mesenchymal Subtype

Hypoglycemic Coma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05508	GLUD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS05796	GRID2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GLUD2	MGD	MGI:95753

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GLUD2 - glutamate dehydrogenase 2 Gene

关于 GLUD2

功能概要

GLUD2 基因产物(1)

GLUD2 蛋白结构

GLUD2 蛋白互作信息

关联疾病

直系同源

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GLUD2 - glutamate dehydrogenase 2 Gene

关于 GLUD2

功能概要

GLUD2 基因产物(1)

GLUD2 蛋白结构

GLUD2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z