2. Gene
  3. GPLD1 - glycosylphosphatidylinositol specific phospholipase D1 Gene

GPLD1 - glycosylphosphatidylinositol specific phospholipase D1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：糖基磷脂酰肌醇特异性磷脂酶 D1

种属: Homo sapiens

同用名: PLD; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1

基因 ID: 2822 | 基因类型: protein coding

关于 GPLD1

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,423,969-24,495,287 (from NCBI)

This gene has 6 transcripts (splice variants) and 126 orthologues. Biased expression in liver (RPKM 12.6), skin (RPKM 4.0) and 8 other tissues.

功能概要

许多蛋白质通过糖基磷脂酰肌醇 (GPI) 锚固定在真核细胞质膜的细胞外表面。 GPI 锚是一种在许多血细胞上发现的糖脂。该基因编码的蛋白质是一种 GPI 降解酶。糖基磷脂酰肌醇特异性磷脂酶 D1 水解由磷脂酰肌醇聚糖锚定的蛋白质中的肌醇磷酸键，从而从质膜释放附着的蛋白质。[RefSeq 提供，2008 年 7 月]

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific Phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

GPLD1 基因产物(1)

mRNA Protein Name
NM_001503.4 NP_001494.2 phosphatidylinositol-glycan-specific phospholipase D precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycosylphosphatidylinositol phospholipase D activity IDA
IDA: 通过直接分析推断
1833386 GOA
enables phospholipase D activity IDA
IDA: 通过直接分析推断
2760042 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in GPI anchor release IDA
IDA: 通过直接分析推断
2760042 GOA
involved in GPI anchor release IMP
IMP: 通过突变表型推断
17720976 GOA
involved in cell migration involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
17720976 GOA
involved in cellular response to calcium ion IDA
IDA: 通过直接分析推断
2760042 GOA
involved in cellular response to cholesterol IMP
IMP: 通过突变表型推断
17761367 GOA
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
15907827 GOA
involved in cellular response to pH IDA
IDA: 通过直接分析推断
17761367 GOA
involved in cellular response to triglyceride IMP
IMP: 通过突变表型推断
17761367 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
17761367 GOA
involved in complement receptor mediated signaling pathway IDA
IDA: 通过直接分析推断
15907827 GOA
involved in insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
18328347 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
19135435 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
19135435 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
17720976 GOA
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
17720976 GOA
involved in regulation of cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
18328347 GOA
involved in response to glucose IDA
IDA: 通过直接分析推断
15907827 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19135435 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
1833386 GOA
located in intracellular membrane-bounded organelle IDA
IDA: 通过直接分析推断
1833386 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPLD1 蛋白结构

Zn_dep_PLPC

Zn_dep_PLPC: Zinc dependent phospholipase C (28 - 187)

FG-GAP

FG-GAP: FG-GAP repeat (382 - 417)

FG-GAP

FG-GAP: FG-GAP repeat (450 - 488)

FG-GAP

FG-GAP: FG-GAP repeat (514 - 547)

  • 0
  • 200
  • 400
  • 600
  • 840 a.a.
蛋白主名 其他名称

phosphatidylinositol-glycan-specific phospholipase D

GPI-PLD

关联疾病

疾病名称 别名
Succinic Semialdehyde Dehydrogenase Deficiency

4-Hydroxybutyric Aciduria

Ssadh Deficiency

Gamma-Hydroxybutyric Aciduria

Gaba Metabolic Defect

SSADHD

Ssadh

Succinate-Semialdehyde Dehydrogenase Deficiency

Gamma-Hydroxybutyricaciduria

4-Hydroxybutyricaciduria

Gamma-Hydroxybutyric Acidemia

Succinate Semialdehyde Dehydrogenase Deficiency
Glandular Tularemia
Typhoidal Tularemia
Brill-Zinsser Disease

Recrudescent Typhus

Brill Disease

Brill Zinsser Disease

Brill'S Disease

Latent Typhus

Sporadic Typhus

Typhus, Epidemic Louse-Borne

Recrudescent Typhus Due To Rickettsia Prowazekii

Recrudescent Typhus Fever

Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii

Recrudescent Brill Disease

Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Oculoglandular Tularemia
Epidemic Typhus

Typhus

Typhus Fever

Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii

Murine Typhus

Classical Typhus

Endemic Flea-Borne Typhus

Endemic Typhus Fever

Epidemic Louse-Borne Typhus

Famine Fever

Flea-Borne Typhus

Jail Fever

Louse-Borne Typhus

Mexican Typhus

Shop Typhus

Urban Typhus

Brill-Zinsser Disease

Endemic Typhus

Sylvatic Typhus

Epidemic Typhus

European Typhus

Exanthematic Typhus Fever

Exanthematous Typhus

Flea Typhus

Flea-Borne Rickettsiosis

Hospital Fever

Louse-Borne [Epidemic] Typhus

Louse-Borne Rickettsiosis

Moscow Typhus

Murine [Endemic] Typhus

Petechial Fever

Prison Fever

Rat Flea Typhus

Ship Fever

Typhus Exanthematique

Typhus, Endemic Flea-Borne

Typhus, Epidemic Louse-Borne

Typhus Group Rickettsial Disease

Relapsing Fever

Typhus Fever Nos

Typhus Nos

Epidemic Typhus Fever

Louse-Borne Typhus Fever

Classical Typhus Fever

Louse-Borne Tabardillo

Epidemic Typhus Fever Due To Rickettsia Prowazekii

Endemic Murine Typhus

Flea-Borne Typhus Fever

Murine Endemic Flea Typhus

Rat Typhus

Typhus Due To Rickettsia Typhi

Flea-Borne Tabardillo

Rickettsia Typhi Rickettsiosis

Mexican Fever

Murine Flea-Borne Typhus

Mooser Bodies

Tsutsugamushi Fever

Kedani Fever

Mite-Borne Typhus

Mite-Borne Typhus Due To Rickettsia Tsutsugamushi

Scrub Typhus

Tsutsugamushi

Tsutsugamushi Disease

Scrub Mite-Borne Typhus

Sumatran Mite Fever

Japanese River Fever

Kedani Typhus

Rickettsia Tsutsugamushi Rickettsiosis

Sumatran Mite Typhus

Tropical Typhus

Japanese Typhus
African Tick-Bite Fever

Rickettsia Africae Spotted Fever

South African Tick-Bite Fever

African Tick Bite Fever
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05642 GPLD1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20415 Gpld1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26924 Gpld1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GPLD1 VGNC VGNC:67410
Macaca mulatta GPLD1 VGNC VGNC:73120
Bos taurus GPLD1 VGNC VGNC:29536
Mus musculus GPLD1 MGD MGI:106604
Rattus norvegicus GPLD1 RGD RGD:631371
Canis familiaris GPLD1 VGNC VGNC:41384
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