2. Gene
  3. ADGRD1 - adhesion G protein-coupled receptor D1 Gene

ADGRD1 - adhesion G protein-coupled receptor D1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 D1

种属: Homo sapiens

同用名: PGR25; GPR133

基因 ID: 283383 | 基因类型: protein coding

关于 ADGRD1

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,953,907-131,141,469 (from NCBI)

This gene has 16 transcripts (splice variants), 200 orthologues and 42 paralogues. Broad expression in placenta (RPKM 7.4), lung (RPKM 6.8) and 20 other tissues.

功能概要

粘附 G 蛋白偶联受体 (GPCR) ，包括 GPR133，是具有包含多个结构域的长 N 末端的膜结合蛋白。 GPCR 或 GPR 包含 7 个跨膜结构域并通过异三聚体 G 蛋白转导细胞外信号 (Bjarnadottir 等人总结，2004 [PubMed 15203201]) 。[OMIM 提供，2010 年 11 月]

The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

ADGRD1 基因产物(2)

mRNA Protein Name
NM_001330497.2 NP_001317426.1 adhesion G-protein coupled receptor D1 isoform 2
NM_198827.5 NP_942122.2 adhesion G-protein coupled receptor D1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
22025619 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
22025619 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
22025619 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
22025619 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADGRD1 蛋白结构

Laminin_G_3

Laminin_G_3: Concanavalin A-like lectin/glucanases superfamily (100 - 241)

GPS

GPS: GPCR proteolysis site, GPS, motif (509 - 551)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (565 - 802)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 874 a.a.
蛋白主名 其他名称

adhesion G-protein coupled receptor D1

G-protein coupled receptor 133

重组 ADGRD1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76961 GPR133 Protein, Human (HEK293, His) Q6QNK2-1/NP_942122.2 (V26-S570) ≥95%

关联疾病

疾病名称 别名
Usher Syndrome, Type Iic

Usher Syndrome Type 2c

USH2C

Usher Syndrome, Type 2c

Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

Usher Syndrome Type Iic

Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

Usher Syndrome 2c

Usher'S Syndrome Type 2c

Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Intellectual Developmental Disorder, Autosomal Dominant 33

MRD33

Autosomal Dominant Non-Syndromic Intellectual Disability 33

Mental Retardation, Autosomal Dominant 33

Autosomal Dominant Intellectual Developmental Disorder 33

Autosomal Dominant Mental Retardation 33

Mental Retardation, Autosomal Dominant, Type 33
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
Brachial Plexus Lesion

Brachial Plexus Injuries

Brachial Plexus Lesions
Usher Syndrome Type 2

Ush2

Usher Syndrome Type Ii
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-177108 AP-503 Agonist 99.84% 否
HY-175232 GL64 / 否
HY-RS00348 ADGRD1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21814 Adgrd1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28330 Adgrd1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ADGRD1 MGD MGI:3041203
Canis familiaris ADGRD1 VGNC VGNC:52918
Macaca mulatta ADGRD1 VGNC VGNC:99877
Bos taurus ADGRD1 VGNC VGNC:53887
Felis catus ADGRD1 VGNC VGNC:80420
Rattus norvegicus ADGRD1 RGD RGD:1594795
Others ADGRD1 NCBI
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