TRIB2 - tribbles pseudokinase 2 Gene

中文名称：tribbles 假激酶 2

种属: Homo sapiens

同用名: C5FW; TRB2; GS3955

关于 TRIB2

功能概要

该基因编码 Tribbles 家族的三个成员之一。 Tribbles 成员共享一个 Trb 结构域，该结构域与蛋白质丝氨酸-苏氨酸激酶同源，但缺少活性位点赖氨酸并且可能缺少催化功能。 Tribbles 蛋白在许多生理和病理过程中相互作用并调节信号转导通路的活性。该 Tribbles 成员主要诱导造血来源的细胞凋亡。它已被确定为一种受骨髓 (THP-1) 细胞炎症刺激上调的蛋白质，也是一种使转录因子 C/EBPalpha (CCAAT/增强子结合蛋白 alpha) 失活并导致急性髓性白血病的致癌基因。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2009 年 3 月]

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces Apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]