GRIK3 - glutamate ionotropic receptor kainate type subunit 3 Gene

中文名称：谷氨酸离子型受体红藻氨酸亚基 3

种属: Homo sapiens

同用名: EAA5; GLR7; GLUR7; GluK3; GluR7a

关于 GRIK3

功能概要

谷氨酸受体是哺乳动物大脑中主要的兴奋性神经递质受体，在各种正常的神经生理过程中被激活。该基因产物属于谷氨酸受体的红藻氨酸家族，由四个亚基组成，起着配体激活离子通道的作用。不确定该基因编码的亚基是否像其他 2 个家族成员 (GRIK1 和 GRIK2) 一样受到 RNA 编辑。 Ser310Ala 多态性与精神分裂症有关，关于其与酗酒者震颤性谵妄发病机制的关联存在相互矛盾的报道。[RefSeq 提供，2008 年 7 月]

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the Other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]