2. Gene
  3. Capn2 - calpain 2 Gene

Capn2 - calpain 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29154 | 基因类型: protein coding

关于 Capn2

功能概要

Enables calcium ion binding activity; cytoskeletal protein binding activity; and enzyme binding activity. Contributes to calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of cell death; and positive regulation of myoblast fusion. Located in several cellular components, including external side of plasma membrane; focal adhesion; and neuronal cell body. Colocalizes with mitochondrial intermembrane space. Biomarker of hypertrophic cardiomyopathy and sciatic neuropathy. Orthologous to human CAPN2 (calpain 2). [provided by Alliance of Genome Resources, Apr 2022]

Capn2 基因产物(1)

mRNA Protein Name
NM_017116.2 NP_058812.1 calpain-2 catalytic subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
14976200 RGD
contributes to calcium-dependent cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
7982961 RGD
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
14976200 RGD
enables cytoskeletal protein binding IDA
IDA: 通过直接分析推断
17429681 RGD
enables enzyme binding IPI
IPI: 通过物理相互作用推断
20850499 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15476820 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
7982961 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to pain IDA
IDA: 通过直接分析推断
25150005 RGD
involved in cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
22711986 RGD
involved in cellular response to interferon-beta IEP
IEP: 通过表达模式推断
23390485 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
23390485 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
24271063 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
21268078 RGD
involved in positive regulation of myoblast fusion IMP
IMP: 通过突变表型推断
7657725 RGD
involved in positive regulation of phosphatidylcholine biosynthetic process IMP
IMP: 通过突变表型推断
9481489 RGD
involved in protein autoprocessing IDA
IDA: 通过直接分析推断
17182728 RGD
involved in protein catabolic process IDA
IDA: 通过直接分析推断
17402852 RGD
involved in proteolysis IDA
IDA: 通过直接分析推断
22711986 RGD
involved in regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
25150005 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
15101113 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
15979593 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
17182728 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell projection IDA
IDA: 通过直接分析推断
12404510 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
22711986 RGD
located in dendrite IDA
IDA: 通过直接分析推断
22711986 RGD
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
9299163 RGD
located in focal adhesion IDA
IDA: 通过直接分析推断
24271063 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
12404510 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

calpain-2 catalytic subunit

CANP 2

M-calpain

calcium-activated neutral proteinase 2

calpain 2, (m/II) large subunit

calpain II

calpain M-type

calpain-2 large subunit

millimolar-calpain

Capn2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Capn2 Q07009 srp-6 Caenorhabditis elegans G5EFH4
Enzymatic Study
17889653
种属内
Capn2 Q07009 Cast Rattus norvegicus P27321
X-Ray Diffraction
19020623
种属内
Capn2 Q07009 Cast Rattus norvegicus P27321
X-Ray Diffraction
19020622
种属内
Capn2 Q07009 Cast Rattus norvegicus P27321
GMS
19020623
种属内
Capn2 Q07009 Cast Rattus norvegicus P27321
NMR
19020622
种属内
Capn2 Q07009 Cast Rattus norvegicus P27321
GMS
19020622
种属内
Capn2 Q07009 Cast Rattus norvegicus P27321
SPR
17543955
种属内
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
X-Ray Diffraction
19020622
种属内
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
GMS
19020623
种属内
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
GMS
19020622
种属内
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
X-Ray Diffraction
10601010
种属内
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
NMR
19020622
种属内
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
X-Ray Diffraction
19020623
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01889 CAPN2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01896 CAPNS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18379 Capn2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24859 Capn2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Capn2 NCBI NCBI:824
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