2. Gene
  3. Flna - filamin A Gene

Flna - filamin A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: RGD1560614

基因 ID: 293860 | 基因类型: protein coding

关于 Flna

功能概要

Enables SMAD binding activity and mu-type Opioid Receptor binding activity. Involved in several processes, including animal organ development; mRNA transcription by RNA polymerase II; and protein localization to bicellular tight junction. Located in several cellular components, including cytoskeleton; dendrite; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Colocalizes with actin filament. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in X-linked recessive disease (multiple); bone development disease (multiple); heart valve disease (multiple); periventricular nodular heterotopia; and terminal osseous dysplasia. Orthologous to human FLNA (filamin A). [provided by Alliance of Genome Resources, Apr 2022]

Flna 基因产物(1)

mRNA Protein Name
NM_001134599.1 NP_001128071.1 filamin-A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SMAD binding IPI
IPI: 通过物理相互作用推断
20167606 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15505042 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
22948144 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
22076441 RGD
involved in establishment of Sertoli cell barrier IMP
IMP: 通过突变表型推断
22872576 RGD
involved in formation of radial glial scaffolds IMP
IMP: 通过突变表型推断
22076441 RGD
involved in mRNA transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20167606 RGD
involved in positive regulation of actin filament bundle assembly IMP
IMP: 通过突变表型推断
22872576 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
22076441 RGD
involved in positive regulation of neuron migration IMP
IMP: 通过突变表型推断
22076441 RGD
involved in protein localization to bicellular tight junction IMP
IMP: 通过突变表型推断
22872576 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
20167606 RGD
located in actin filament IDA
IDA: 通过直接分析推断
15661894 RGD
located in apical dendrite IDA
IDA: 通过直接分析推断
22434607 RGD
located in cell cortex IDA
IDA: 通过直接分析推断
22872576 RGD
located in cortical cytoskeleton IDA
IDA: 通过直接分析推断
15661894 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
22434607 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
26972007 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
22434607 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
20167606 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
26972007 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

filamin-A

Endothelial actin-binding protein 280)

actin binding protein 280

filamin A, alpha

filamin, alpha

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-139142B Simufilam hydrochloride 99.85% Phase 3
HY-139142 Simufilam 98.08% Phase 3
HY-139142A Simufilam dihydrochloride / Phase 3
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04979 FLNA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18476 Flna Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24957 Flna Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Flna NCBI NCBI:2316
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