2. Gene
  3. Htt - huntingtin Gene

Htt - huntingtin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Hd; Hdh

基因 ID: 29424 | 基因类型: protein coding

关于 Htt

功能概要

Enables signaling receptor binding activity. Involved in several processes, including mRNA transport; negative regulation of cysteine-type endopeptidase activity; and regulation of intracellular mRNA localization. Located in several cellular components, including neuronal cell body; neuronal ribonucleoprotein granule; and postsynaptic density. Used to study Huntington's disease. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (Huntingtin). [provided by Alliance of Genome Resources, Apr 2022]

Htt 基因产物(1)

mRNA Protein Name
NM_024357.4 NP_077333.2 huntingtin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9454836 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
12873381 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA transport IMP
IMP: 通过突变表型推断
22355657 RGD
involved in microtubule depolymerization IMP
IMP: 通过突变表型推断
20858895 RGD
involved in negative regulation of cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
17124493 RGD
involved in regulation of intracellular mRNA localization IMP
IMP: 通过突变表型推断
20185826 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
22355657 RGD
located in clathrin-coated vesicle IDA
IDA: 通过直接分析推断
20739295 RGD
located in dendrite IDA
IDA: 通过直接分析推断
22355657 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
22355657 RGD
located in neuronal ribonucleoprotein granule IDA
IDA: 通过直接分析推断
22355657 RGD
located in synaptic membrane IDA
IDA: 通过直接分析推断
12650982 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

huntingtin

HD protein homolog

Huntington disease gene homolog

huntingtin (Huntington disease)

huntington disease protein homolog

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-132579 Tominersen 94.13% Phase 3
HY-132593 Rovanersen / Phase 2
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16009 Buntanetap 99.71% 否
HY-156650 Votoplam Modulator 99.51% 否
HY-132579A Tominersen sodium 97.36% 否
HY-136780 SEN177 Inhibitor 98.76% 否
HY-156103 mHTT-IN-2 Inhibitor 99.35% 否
HY-150236 FITC-labeled Tominersen sodium Inhibitor 95.72% 否
HY-132593A Rovanersen sodium 95.58% 否
HY-16009B Buntanetap L-Tartrate 98.93% 否
HY-143792 HTT-D3 Inhibitor / 否
HY-10542A (Z)-GW 5074 Inhibitor / 否
HY-P10822 ED11 Inhibitor / 否
HY-RS06490 HTT Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13311 SLC6A4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13312 Slc6a4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-W792458 MADAM Ligand / 否
HY-RS18021 Htt Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24494 Htt Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htt NCBI NCBI:3064
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