2. Gene
  3. Scn1b - sodium voltage-gated channel beta subunit 1 Gene

Scn1b - sodium voltage-gated channel beta subunit 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29686 | 基因类型: protein coding

关于 Scn1b

功能概要

Enables Sodium Channel regulator activity. Involved in regulation of voltage-gated Sodium Channel activity and response to pyrethroid. Is integral component of plasma membrane. Part of voltage-gated Sodium Channel complex. Colocalizes with node of Ranvier. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Scn1b 基因产物(3)

mRNA Protein Name
NM_001271045.2 NP_001257974.1 sodium channel subunit beta-1 isoform 1 precursor
NM_001271046.2 NP_001257975.1 sodium channel subunit beta-1 isoform 2
NM_017288.3 NP_058984.1 sodium channel subunit beta-1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10737807 RGD
enables sodium channel regulator activity IDA
IDA: 通过直接分析推断
17517192 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of sodium ion transport IDA
IDA: 通过直接分析推断
1375395 RGD
involved in regulation of voltage-gated sodium channel activity IDA
IDA: 通过直接分析推断
28012039 RGD
involved in response to pyrethroid IDA
IDA: 通过直接分析推断
19026681 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in node of Ranvier IDA
IDA: 通过直接分析推断
11470829 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
11470829 RGD
part of voltage-gated sodium channel complex IDA
IDA: 通过直接分析推断
1375395 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sodium channel subunit beta-1

sodium channel, voltage-gated, type 1, beta polypeptide

sodium channel, voltage-gated, type I, beta polypeptide

sodium channel, voltage-gated, type I, beta subunit

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12528 SCN1B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22797 Scn1b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29311 Scn1b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Scn1b NCBI NCBI:6324
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