TRPM5 - transient receptor potential cation channel subfamily M member 5 Gene

中文名称：瞬时受体电位阳离子通道亚家族 M 成员 5

种属: Homo sapiens

同用名: MTR1; LTRPC5

关于 TRPM5

功能概要

该基因编码瞬时受体电位 (TRP) 蛋白家族的成员，该家族是一组具有典型离子通道结构特征的蛋白质。这种蛋白质在味觉传导中起着重要作用，并具有钙激活的非选择性阳离子通道的特征，它同样能够很好地携带 Na+、K+ 和 Cs+ 离子，但不能携带 CA (2+) 离子。它被较低浓度的细胞内 CA (2+) 激活，并被较高浓度抑制。它也是一个对温度高度敏感的热激活通道，在 15 至 35 摄氏度的温度下，内向电流会急剧增加。该基因位于 Beckwith-Wiedemann 综合征关键区域 1 的染色体 11p15.5 内，并已被证明具有印记，具有来自父系等位基因的独特表达。[RefSeq 提供，2010 年 10 月]

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not CA(2+) ions. It is activated by lower concentrations of intracellular CA(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]