1. Gene
  2. Grik3 - glutamate ionotropic receptor kainate type subunit 3 Gene

Grik3 - glutamate ionotropic receptor kainate type subunit 3 Gene

种属: Rattus norvegicus

同用名: GluK3; GluR7; gluR-7

基因 ID: 298521 | 基因类型: protein coding

关于 Grik3

功能概要

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Compared to Other kainate or AMPA receptors, this subunit exhibits a lower sensitivity to glutamate, and thus may play a unique role in neurotransmission in the brain. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Grik3 基因产物(2)

mRNA Protein Name
NM_001112716.1 NP_001106187.1 glutamate receptor ionotropic, kainate 3 isoform 1 precursor
NM_181373.3 NP_852038.2 glutamate receptor ionotropic, kainate 3 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutamate receptor activity IDA
IDA: 通过直接分析推断
9390526 RGD
enables glutamate-gated receptor activity IDA
IDA: 通过直接分析推断
1322826 RGD
enables glutamate-gated receptor activity IMP
IMP: 通过突变表型推断
21907808 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
31311973 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
34706237 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of synaptic transmission, glutamatergic IDA
IDA: 通过直接分析推断
16420445 RGD
acts upstream of or within regulation of membrane potential IDA
IDA: 通过直接分析推断
11124978 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
15844209 RGD
is active in cochlear hair cell ribbon synapse IDA
IDA: 通过直接分析推断
24858010 RGD
located in dendrite IDA
IDA: 通过直接分析推断
16360275 RGD
located in dendrite cytoplasm IDA
IDA: 通过直接分析推断
15844209 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
15844209 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
24858010 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
15844209 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

glutamate receptor ionotropic, kainate 3

glutamate receptor 7

glutamate receptor subunit kainate subtype

glutamate receptor, ionotropic, kainate 3

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grik3 NCBI NCBI:2899