2. Gene
  3. GUK1 - guanylate kinase 1 Gene

GUK1 - guanylate kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟苷酸激酶 1

种属: Homo sapiens

同用名: GMK

基因 ID: 2987 | 基因类型: protein coding

关于 GUK1

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,140,084-228,148,955 (from NCBI)

This gene has 39 transcripts (splice variants) and 306 orthologues. Ubiquitous expression in bone marrow (RPKM 25.0), adrenal (RPKM 18.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种酶，可催化磷酸基团从 ATP 转移到鸟苷一磷酸 (GMP) 以形成鸟苷二磷酸 (GDP) 。编码的蛋白质被认为是癌症化学疗法的良好靶标。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2011 年 6 月]

The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for Cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GUK1 基因产物(5)

mRNA Protein Name
NM_000858.7 NP_000849.1 guanylate kinase isoform b
NM_001159390.2 NP_001152862.1 guanylate kinase isoform a
NM_001159391.3 NP_001152863.1 guanylate kinase isoform b
NM_001242839.1 NP_001229768.1 guanylate kinase isoform b
NM_001242840.3 NP_001229769.1 guanylate kinase isoform c
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanylate kinase activity EXP
EXP: 通过实验结果推断
8663313 GOA
enables guanylate kinase activity IDA
IDA: 通过直接分析推断
8663313 GOA
enables guanylate kinase activity IMP
IMP: 通过突变表型推断
31201273 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dGDP biosynthetic process IMP
IMP: 通过突变表型推断
31201273 GOA
involved in purine nucleotide metabolic process IDA
IDA: 通过直接分析推断
8663313 GOA
involved in xenobiotic metabolic process IDA
IDA: 通过直接分析推断
6306664 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GUK1 蛋白结构

Guanylate_kin

Guanylate_kin: Guanylate kinase (5 - 187)

  • 0
  • 100
  • 197 a.a.
蛋白主名 其他名称

guanylate kinase

ATP:GMP phosphotransferase

GUK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GUK1 Q16774 TTC19 Homo sapiens Q6DKK2
Anti Tag CoIP
33961781
种属内
GUK1 Q16774 TTC19 Homo sapiens Q6DKK2
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cataract 6, Multiple Types

Ctpp1

Cataract 6 Multiple Types

CTRCT6

Cataract, Posterior Polar, 1

Arcc2

Cataract, Age-Related Cortical, 2

Ctpa

Ctpp

Age Related Cortical Cataract 2

Posterior Polar Cataract 1

Posterior Polar Cataract, 1

Age-Related Cortical Cataract 2

Cataract Posterior Polar 1
Internal Hordeolum
Cataract 28

CTRCT28

Cataract, Age-Related Cortical, 1

Arcc1

Cataract 28, Age-Related Cortical, Susceptibility To

Cataract 28, Age-Related Cortical

Age-Related Cortical Cataract 1
Brugada Syndrome 4

BRGDA4

Brugada Syndrome, Type 4
Staphyloenterotoxemia

Staphylococcal Food Poisoning

Staphylococcal Toxaemia Due To Food

Staphyloenterotoxicosis
Ankylosis
Orbital Cellulitis

Cellulitis Of Orbit
Acute Orbital Inflammation

Acute Inflammation Of Orbit
Endocardium Disease
Ritter'S Disease

Staphylococcal Scalded Skin Syndrome

Pemphigus Neonatorum

Ritter Disease

Dermatitis Exfoliativa Neonatorum

Scalded Skin Syndrome

Toxic Epidermal Necrolysis, Subcorneal Type

Generalized Exfoliative Disease

Ssss

Ssss - [Staphylococcal Scalded Skin Syndrome]
Commensal Bacterial Infectious Disease
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05924 GUK1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GUK1 VGNC VGNC:29725
Felis catus GUK1 VGNC VGNC:67520
Mus musculus GUK1 MGD MGI:95871
Macaca mulatta GUK1 VGNC VGNC:73331
Canis familiaris GUK1 VGNC VGNC:54767
Rattus norvegicus GUK1 RGD RGD:1309638
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