2. Gene
  3. RHOD - ras homolog family member D Gene

RHOD - ras homolog family member D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ras 同系物家族成员 D

种属: Homo sapiens

同用名: Rho; ARHD; RHOM; RHOHP1

基因 ID: 29984 | 基因类型: protein coding

关于 RHOD

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,056,847-67,072,017 (from NCBI)

This gene has 3 transcripts (splice variants), 100 orthologues and 22 paralogues. Ubiquitous expression in esophagus (RPKM 14.1), skin (RPKM 7.1) and 20 other tissues.

功能概要

Ras 同系物或 Rho 蛋白与蛋白激酶相互作用，可作为活化 GTP 酶的靶标。它们在肌肉分化中起关键作用。该基因编码的蛋白质结合 GTP，是小 GTPase 超家族的成员。它参与内体动力学和肌动蛋白细胞骨架的重组，并且它可以协调膜转运与细胞骨架的功能。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2014 年 7 月]

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin Cytoskeleton, and it may coordinate membrane transport with the function of the Cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

RHOD 基因产物(2)

mRNA Protein Name
NM_001300886.2 NP_001287815.1 rho-related GTP-binding protein RhoD isoform 2
NM_014578.4 NP_055393.1 rho-related GTP-binding protein RhoD isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18218625 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament bundle assembly IMP
IMP: 通过突变表型推断
23087206 GOA
involved in focal adhesion assembly IMP
IMP: 通过突变表型推断
23087206 GOA
involved in lamellipodium assembly IMP
IMP: 通过突变表型推断
23087206 GOA
involved in positive regulation of cell adhesion IMP
IMP: 通过突变表型推断
23087206 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
23087206 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RHOD 蛋白结构

Ras

Ras: Ras family (19 - 190)

  • 0
  • 100
  • 210 a.a.
蛋白主名 其他名称

rho-related GTP-binding protein RhoD

Rho-related protein HP1

RHOD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RHOD O00212 DAAM1 Homo sapiens Q9Y4D1
Pull Down
18218625
种属内
RHOD O00212 DAAM1 Homo sapiens Q9Y4D1
Anti Tag CoIP
33961781
种属内
RHOD O00212 DIAPH1 Homo sapiens O60610
Pull Down
18218625
种属内
RHOD O00212 DIAPH1 Homo sapiens O60610
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Clostridium Difficile Colitis

Pseudomembranous Colitis

Colitis Pseudomembranous

Enterocolitis, Pseudomembranous

Pseudomembranous Enterocolitis

Clostridium Difficile Infection
Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2
Tangier Disease

Analphalipoproteinemia

High Density Lipoprotein Deficiency, Tangier Type

TGD

High Density Lipoprotein Deficiency, Type 1

Hdldt1

Familial High Density Lipoprotein Deficiency

A-Alphalipoprotein Neuropathy

Alpha High Density Lipoprotein Deficiency Disease

Cholesterol Thesaurismosis

Familial High Density Lipoprotein Deficiency Disease

Hdl Lipoprotein Deficiency Disease

Tangier Disease Neuropathy

Familial Alpha-Lipoprotein Deficiency

Familial High-Density Lipoprotein Deficiency 1

Primary Hypoalphalipoproteinemia 1

Analphalipo-Proteinemia

Familial Hypoalphalipo-Proteinemia

Familial Hypoalphalipoproteinemia

Lipoprotein Deficiency Disease, Hdl, Familial

Tangier Hereditary Neuropathy

Atp-Binding Cassette Transporter A1 Deficiency

Hdld1

High Density Lipoprotein Deficiency 1

Tangier Disease, Variant

Hypoalphalipoproteinemia, Familial

Familial Hdl Deficiency
Toxic Megacolon

Megacolon, Toxic

Toxic Dilatation Of Colon

Toxic Functional Megacolon
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Vascular Anomaly

Spinal Cord Vascular Diseases

Vascular Tissue Disease
Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive

Autosomal Recessive Centronuclear Myopathy

CNM2

Centronuclear Myopathy 2

Ar-Cnm

Myotubular Myopathy, Autosomal Recessive

Autosomal Recessive Myotubular Myopathy

Centronuclear Myopathy Autosomal Recessive

Myopathy, Centronuclear, Type 2
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-D0989 Rhod-2 AM ≥97.0% 否
HY-D1005 Poloxamer 407 (F127) Inhibitor / 否
HY-162543 18:1 Liss Rhod PE 99% 否
HY-W127775 Demethyl Rhod-2 AM / 否
HY-104057 Rhod-FF AM / 否
HY-136784 Rhod-2 potassium / 否
HY-136894 Rhod-5N / 否
HY-D1681 Rhod-590 AM Ester / 否
HY-RS11951 RHOD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W127781 RHOD 2 triammonium / 否
HY-136784A Rhod-2 sodium / 否
HY-172627 Rhod-FF tripotassium / 否
HY-RS22304 Rhod Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28827 Rhod Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RHOD VGNC VGNC:104322
Bos taurus RHOD VGNC VGNC:33947
Mus musculus RHOD MGD MGI:108446
Macaca mulatta RHOD VGNC VGNC:81556
Canis familiaris RHOD VGNC VGNC:45558
Rattus norvegicus RHOD RGD RGD:1310985
Others RHOD NCBI
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