KCNIP3 - potassium voltage-gated channel interacting protein 3 Gene

中文名称：钾电压门控通道相互作用蛋白 3

种属: Homo sapiens

同用名: CSEN; DREAM; KCHIP3

基因 ID: 30818 | 基因类型: protein coding

关于 KCNIP3

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,297,347-95,386,077 (from NCBI)

This gene has 8 transcripts (splice variants), 275 orthologues and 14 paralogues. Broad expression in brain (RPKM 13.6), thyroid (RPKM 9.3) and 14 other tissues.

功能概要

该基因编码电压门控钾 (Kv) 通道相互作用蛋白家族的成员，属于 EF 手超家族的恢复蛋白分支。该家族的成员是含有 EF 手样结构域的小型钙结合蛋白。它们是天然 Kv4 通道复合物的完整亚基成分，可调节 A 型电流，从而响应细胞内钙的变化调节神经元兴奋性。编码的蛋白质还充当钙调节转录抑制因子，并与早老素相互作用。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

KCNIP3 基因产物(2)

mRNA	Protein	Name
NM_001034914.2	NP_001030086.1	calsenilin isoform 2 precursor
NM_013434.5	NP_038462.1	calsenilin isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	10078534	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	10078534	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10078534	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCNIP3 蛋白结构

EF-hand_8

EF-hand_7

0
100
200
256 a.a.

蛋白主名

其他名称

calsenilin

A-type potassium channel modulatory protein 3

KCNIP3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KCNIP3	Q9Y2W7	SOD3	Homo sapiens	P08294	Y2H Prey Pooling	32296183
种属内	KCNIP3	Q9Y2W7	SOD3	Homo sapiens	P08294	Y2H Array	32296183
种属内	KCNIP3	Q9Y2W7	IL6ST	Homo sapiens	Q17RA0	Y2H Array	25416956
种属内	KCNIP3	Q9Y2W7	IL6ST	Homo sapiens	P40189	Y2H Prey Pooling	32296183
种属内	KCNIP3	Q9Y2W7	IL6ST	Homo sapiens	P40189	Y2H Array	32296183
种属内	KCNIP3	Q9Y2W7	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Array	32296183
种属内	KCNIP3	Q9Y2W7	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Prey Pooling	32296183
种属内	KCNIP3	Q9Y2W7	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Array	32296183
种属内	KCNIP3	Q9Y2W7	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Prey Pooling	32296183
种属内	KCNIP3	Q9Y2W7	RPSA	Homo sapiens	P08865	Validated Y2H	32814053
种属内	KCNIP3	Q9Y2W7	RPSA	Homo sapiens	P08865	Y2H Array	32814053
种属内	KCNIP3	Q9Y2W7	RPSA	Homo sapiens	P08865	Y2H Pooling	32814053
种属内	KCNIP3	Q9Y2W7	GOLGA7	Homo sapiens	Q7Z5G4	Y2H Array	32296183
种属内	KCNIP3	Q9Y2W7	GOLGA7	Homo sapiens	Q7Z5G4	Y2H Prey Pooling	32296183
种属内	KCNIP3	Q9Y2W7	IGF1R	Homo sapiens	P08069	Y2H Prey Pooling	25416956
种属内	KCNIP3	Q9Y2W7	CD177	Homo sapiens	Q8N6Q3	Y2H Pooling	16189514
种属内	KCNIP3	Q9Y2W7	CD177	Homo sapiens	Q8N6Q3	Y2H Prey Pooling	25416956
种属内	KCNIP3	Q9Y2W7	CD177	Homo sapiens	Q8N6Q3	Validated Y2H	25416956
种属内	KCNIP3	Q9Y2W7	KHDC4	Homo sapiens	Q7Z7F0-4	Y2H Array	32296183
种属内	KCNIP3	Q9Y2W7	KHDC4	Homo sapiens	Q7Z7F0-4	Y2H Prey Pooling	32296183
种属内	KCNIP3	Q9Y2W7	MAVS	Homo sapiens	Q7Z434	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 KCNIP3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75691	CSEN Protein, Human (His)	Q9Y2W7-1 (M1-I256)	≥95%

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 20

DBA20

Rps15a-Related Diamond-Blackfan Anemia

Renal Artery Obstruction

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07134	KCNIP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20559	Kcnip3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27068	Kcnip3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	KCNIP3	VGNC	VGNC:73834
Bos taurus	KCNIP3	VGNC	VGNC:102823
Canis familiaris	KCNIP3	VGNC	VGNC:42256
Mus musculus	KCNIP3	MGD	MGI:1929258
Rattus norvegicus	KCNIP3	RGD	RGD:70888
Felis catus	KCNIP3	VGNC	VGNC:63042
Others	KCNIP3	NCBI

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