2. Gene
  3. Bin1 - bridging integrator 1 Gene

Bin1 - bridging integrator 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ALP-1; Amphl; SH3P9; BRAMP-2

基因 ID: 30948 | 基因类型: protein coding

关于 Bin1

功能概要

Enables aspartic-type endopeptidase inhibitor activity and Tau Protein binding activity. Involved in several processes, including negative regulation of amyloid precursor protein catabolic process; negative regulation of cation transmembrane transport; and regulation of heart contraction. Acts upstream of or within muscle cell differentiation. Located in several cellular components, including T-tubule; dendrite; and nuclear envelope. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; heart; and musculature. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1). [provided by Alliance of Genome Resources, Apr 2022]

Bin1 基因产物(3)

mRNA Protein Name
NM_001083334.1 NP_001076803.1 myc box-dependent-interacting protein 1 isoform 2
NM_001360876.1 NP_001347805.1 myc box-dependent-interacting protein 1 isoform 3
NM_009668.2 NP_033798.1 myc box-dependent-interacting protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aspartic-type endopeptidase inhibitor activity IMP
IMP: 通过突变表型推断
27179792 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8782822 MGI
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
35263589 MGI
enables tau protein binding IPI
IPI: 通过物理相互作用推断
23399914 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T-tubule organization IMP
IMP: 通过突变表型推断
24836577 MGI
acts upstream of or within muscle cell differentiation IMP
IMP: 通过突变表型推断
10036185 MGI
involved in negative regulation of amyloid-beta formation IMP
IMP: 通过突变表型推断
27179792 MGI
involved in negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
IMP: 通过突变表型推断
27179792 MGI
involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: 通过突变表型推断
24836577 MGI
involved in negative regulation of potassium ion transmembrane transport IMP
IMP: 通过突变表型推断
24836577 MGI
involved in negative regulation of ventricular cardiac muscle cell action potential IMP
IMP: 通过突变表型推断
24836577 MGI
involved in nucleus localization IMP
IMP: 通过突变表型推断
26506308 MGI
involved in positive regulation of actin filament polymerization IDA
IDA: 通过直接分析推断
24836577 MGI
involved in regulation of heart rate by cardiac conduction IMP
IMP: 通过突变表型推断
24836577 MGI
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
35263589 MGI
involved in synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
11879655 MGI
involved in synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
11879655 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
24836577 MGI
located in axon IDA
IDA: 通过直接分析推断
32552912 MGI
located in dendrite IDA
IDA: 通过直接分析推断
32552912 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11879655 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
11879655 MGI
located in nuclear envelope IDA
IDA: 通过直接分析推断
26506308 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8782822 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
30967682 MGI
is active in presynapse IDA
IDA: 通过直接分析推断
30967682 MGI
is active in synapse EXP
EXP: 通过实验结果推断
24534009 MGI
is active in synapse IDA
IDA: 通过直接分析推断
24534009 MGI
located in vesicle IDA
IDA: 通过直接分析推断
32552912 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

myc box-dependent-interacting protein 1

SH3 domain-containing protein 9

amphiphysin 2

amphiphysin II

amphiphysin-like protein

相关产品

Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139561 KDM2B-IN-2 99.36% 否
HY-10704 PTP1B-IN-1 Inhibitor 99.65% 否
HY-139560 KDM2B-IN-1 Inhibitor 99.19% 否
HY-126246 CDC25B-IN-1 Inhibitor 98.12% 否
HY-147646 CDK1/Cyc B-IN-1 98.47% 否
HY-135711 PDE8B-IN-1 99.91% 否
HY-136556 Factor B-IN-1 Inhibitor 95.0% 否
HY-162811 LAG-3 biner 1 97.08% 否
HY-117848 PDE8B-IN-1 hydrochloride Inhibitor / 否
HY-142957 NaPi2b-IN-1 Inhibitor / 否
HY-145695 Dual AChE-MAO B-IN-1 Inhibitor / 否
HY-147945 DNA gyrase B-IN-1 Inhibitor / 否
HY-163285 PDE3B-IN-1 Inhibitor / 否
HY-168185 α-glucosidase/PTP1B-IN-1 Inhibitor / 否
HY-176762 TOP3B-IN-1 Inhibitor / 否
HY-RS01504 BIN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-170412 Cox B-IN-1 Inhibitor / 否
HY-170810 E.coli Gyrase B-IN-1 Inhibitor / 否
HY-RS18913 Bin1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25404 Bin1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bin1 NCBI NCBI:274
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z