2. Gene
  3. AOAH - acyloxyacyl hydrolase Gene

AOAH - acyloxyacyl hydrolase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酰氧酰基水解酶

种属: Homo sapiens

基因 ID: 313 | 基因类型: protein coding

关于 AOAH

Cytogenetic location: 7p14.2 Genomic coordinates (GRCh38): 7:36,512,941-36,724,494 (from NCBI)

This gene has 12 transcripts (splice variants) and 122 orthologues. Biased expression in spleen (RPKM 9.9), appendix (RPKM 5.8) and 13 other tissues.

功能概要

该基因座编码酰氧基酰基水解酶的轻亚基和重亚基。编码的酶催化细菌脂多糖中酰氧基酰基连接的脂肪酰基链的水解，有效地解毒这些分子。编码的蛋白质可能在调节宿主对革兰氏阴性菌的炎症反应中发挥作用。已经描述了选择性剪接的转录变体。[RefSeq 提供，2010 年 4 月]

This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from Bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]

AOAH 基因产物(3)

mRNA Protein Name
NM_001177506.2 NP_001170977.1 acyloxyacyl hydrolase isoform 2 preproprotein
NM_001177507.2 NP_001170978.1 acyloxyacyl hydrolase isoform 3 preproprotein
NM_001637.4 NP_001628.1 acyloxyacyl hydrolase isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acyloxyacyl hydrolase activity IDA
IDA: 通过直接分析推断
1883828 GOA
enables calcium ion binding IDA
IDA: 通过直接分析推断
29343645 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid metabolic process IDA
IDA: 通过直接分析推断
1883828 GOA
involved in lipopolysaccharide catabolic process IDA
IDA: 通过直接分析推断
1883828 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AOAH 蛋白结构

SapB_2

SapB_2: Saposin-like type B, region 2 (81 - 114)

Lipase_GDSL

Lipase_GDSL: GDSL-like Lipase/Acylhydrolase (257 - 534)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
蛋白主名 其他名称

acyloxyacyl hydrolase

acyloxyacyl hydrolase (neutrophil)

AOAH 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AOAH P28039 DLG2 Homo sapiens Q15700
Y2H Prey Pooling
32296183
种属内
AOAH P28039 DLG2 Homo sapiens Q15700
Y2H Array
32296183
种属内
AOAH P28039 DLG2 Homo sapiens Q15700
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chronic Frontal Sinusitis
Acute Ethmoiditis

Acute Ethmoidal Sinusitis

Acute Ethmoid Sinusitis

Ethmoidal Sinus - Acute
Xanthogranulomatous Pyelonephritis

Pyelonephritis, Xanthogranulomatous
Cervix Endometriosis

Endometriosis Of Cervix

Cervical Endometriosis
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00770 AOAH Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus AOAH VGNC VGNC:25971
Rattus norvegicus AOAH RGD RGD:1560514
Macaca mulatta AOAH VGNC VGNC:69954
Mus musculus AOAH MGD MGI:1350928
Canis familiaris AOAH VGNC VGNC:37946
Felis catus AOAH VGNC VGNC:67717
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