2. Gene
  3. Lck - LCK proto-oncogene, Src family tyrosine kinase Gene

Lck - LCK proto-oncogene, Src family tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Lck1; Lcktkr

基因 ID: 313050 | 基因类型: protein coding

关于 Lck

功能概要

Enables antigen binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of uterine smooth muscle contraction; protein phosphorylation; and response to hydrogen peroxide. Located in endocytic vesicle; membrane raft; and plasma membrane. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study allergic conjunctivitis and human immunodeficiency virus infectious disease. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human Lck (Lck proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lck 基因产物(1)

mRNA Protein Name
NM_001100709.1 NP_001094179.1 proto-oncogene tyrosine-protein kinase LCK
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables antigen binding IPI
IPI: 通过物理相互作用推断
18178839 RGD
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
11034334 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
8104794 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
11034334 RGD
involved in positive regulation of uterine smooth muscle contraction IMP
IMP: 通过突变表型推断
19208792 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
11034334 RGD
involved in response to aldosterone IEP
IEP: 通过表达模式推断
29713904 RGD
involved in response to hydrogen peroxide IDA
IDA: 通过直接分析推断
9325251 RGD
involved in response to mechanical stimulus IMP
IMP: 通过突变表型推断
19208792 RGD
involved in response to metal ion IDA
IDA: 通过直接分析推断
11477538 RGD
involved in response to zinc ion IEP
IEP: 通过表达模式推断
14652378 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endocytic vesicle IDA
IDA: 通过直接分析推断
9116282 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
14529711 RGD
is active in postsynaptic specialization, intracellular component IDA
IDA: 通过直接分析推断
14529711 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

proto-oncogene tyrosine-protein kinase LCK

lymphocyte cell-specific protein-tyrosine kinase

lymphocyte protein tyrosine kinase

lymphocyte-specific protein tyrosine kinase

p56-LCK

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Phase 2
HY-157442 GLPG3312 Inhibitor 98.57% Phase 1
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132166 Velzatinib Inhibitor 99.47% 否
HY-13561 AZM475271 Inhibitor 99.89% 否
HY-112291 SB 220025 Inhibitor 99.90% 否
HY-15324 PRT062607 acetate Inhibitor 99.83% 否
HY-118105 RK-20448 Inhibitor 99.38% 否
HY-176194 Antifibrotic agent 1 Inhibitor / 否
HY-163278 Lck-IN-2 Inhibitor / 否
HY-120622 BMS-243117 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lck NCBI NCBI:3932
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