2. Gene
  3. FOXA3 - forkhead box A3 Gene

FOXA3 - forkhead box A3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 A3

种属: Homo sapiens

同用名: FKHH3; HNF3G; TCF3G

基因 ID: 3171 | 基因类型: protein coding

关于 FOXA3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,864,326-45,873,797 (from NCBI)

This gene has 2 transcripts (splice variants), 89 orthologues and 42 paralogues. Biased expression in liver (RPKM 21.0), stomach (RPKM 17.8) and 6 other tissues.

功能概要

该基因编码叉头类 DNA 结合蛋白的一个成员。这些肝细胞核因子是肝脏特异性转录物 (如白蛋白和转甲状腺素蛋白) 的转录激活因子，它们还与染色质相互作用。小鼠中的相似家族成员在代谢调节以及胰腺和肝脏的分化中发挥作用。大鼠中类似蛋白质的晶体结构已得到解析。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

FOXA3 基因产物(1)

mRNA Protein Name
NM_004497.3 NP_004488.2 hepatocyte nuclear factor 3-gamma

FOXA3 蛋白结构

Forkhead_N

Forkhead_N: Forkhead N-terminal region (16 - 116)

Forkhead

Forkhead: Forkhead domain (117 - 212)

HNF_C

HNF_C: HNF3 C-terminal domain (301 - 322)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

hepatocyte nuclear factor 3-gamma

HNF-3-gamma

FOXA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOXA3 P55318 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
种属内
FOXA3 P55318 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
种属内
FOXA3 P55318 CHAT Homo sapiens P28329-3
Y2H Array
32814053
种属内
FOXA3 P55318 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
FOXA3 P55318 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
FOXA3 P55318 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Adult Acute Monocytic Leukemia

Adult Acute Monoblastic And Acute Monocytic Leukemia
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05038 FOXA3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174678 Human FOXA3 mRNA / 否
HY-RS20927 Foxa3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27444 Foxa3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FOXA3 VGNC VGNC:29079
Felis catus FOXA3 VGNC VGNC:67602
Macaca mulatta FOXA3 VGNC VGNC:72709
Canis familiaris FOXA3 VGNC VGNC:40945
Mus musculus FOXA3 MGD MGI:1347477
Rattus norvegicus FOXA3 RGD RGD:2809
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