2. Gene
  3. HRG - histidine rich glycoprotein Gene

HRG - histidine rich glycoprotein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富组氨酸的糖蛋白

种属: Homo sapiens

同用名: HPRG; HRGP; THPH11

基因 ID: 3273 | 基因类型: protein coding

关于 HRG

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,666,014-186,678,234 (from NCBI)

This gene has 3 transcripts (splice variants), 118 orthologues, 3 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 1677.7).

功能概要

这种富含组氨酸的糖蛋白包含两个胱抑素样结构域，位于血浆和血小板中。生理功能尚未确定，但已知该蛋白质可结合血红素、染料和二价金属离子。编码的蛋白质还具有一种肽，该肽对白色念珠菌、大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和粪肠球菌显示出抗菌活性。它可以抑制玫瑰花结形成并与肝素、血小板反应蛋白和纤溶酶原相互作用。蛋白质的两种作用，纤维蛋白溶解的抑制和凝血抑制的减少，表明潜在的促血栓形成作用。由于富含组氨酸的糖蛋白水平异常，该基因的突变会导致血栓形成倾向。[RefSeq 提供，2014 年 11 月]

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]

HRG 基因产物(1)

mRNA Protein Name
NM_000412.5 NP_000403.1 histidine-rich glycoprotein precursor

HRG 蛋白结构

Cystatin

Cystatin: Cystatin domain (23 - 95)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
蛋白主名 其他名称

histidine-rich glycoprotein

histidine-proline-rich glycoprotein

重组 HRG 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77380 HPRG Protein, Human (HEK293, His) P04196/NP_000403.1 (V19-K525) ≥95%

关联疾病

疾病名称 别名
Thrombophilia Due To Histidine-Rich Glycoprotein Deficiency

THPH11

Thrombophilia 11 Due To Hrg Deficiency
Thrombophilia Due To Hrg Deficiency

Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency

Hereditary Thrombophilia Due To Congenital Hrg Deficiency

Thph11
Thrombophilia

Hypercoagulability State
Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency

Proc Deficiency

Congenital Thrombotic Disease, Due To Protein C Deficiency
Thrombosis

Thrombosis Of Blood Vessel
Prothrombin Thrombophilia

Prothrombin G20210a Thrombophilia

Hyperprothrombinemia
Thrombophilia Due To Thrombin Defect

Venous Thromboembolism

Venous Thrombosis

Thrombophilia Due To Factor 2 Defect

Thromboembolism

THPH1

Thromboembolism, Susceptibility To

Venous Thromboembolism, Susceptibility To

Venous Thrombosis, Protection Against

Prothrombin-Related Thrombophilia

Hyperprothrombinemia

Venous Thrombosis, Susceptibility To

Thrombophilia 1 Due To Thrombin Defect

F2-Related Thrombophilia

Factor Ii-Related Thrombophilia

Prothrombin 20210g>A Thrombophilia

Prothrombin G20210a Thrombophilia

Prothrombin Thrombophilia
Corneal Neovascularization

Corneal Neovascularisation

Corneal Vascularisation

Extensive Superficial Corneal Vascularisation
Plasminogen Deficiency, Type I

Hypoplasminogenemia

Dysplasminogenemia

Plasminogen Deficiency Type I

Congenital Plasminogen Deficiency

Ligneous Conjunctivitis

Type 1 Plasminogen Deficiency

Plasminogen Deficiency Type 1

Plasminogen Deficiency

PLGD

Plasminogen Deficiency Type Ii

Deficiency, Plasminogen, Type I
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06358 HRG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HRG MGD MGI:2146636
Rattus norvegicus HRG RGD RGD:619808
Macaca mulatta HRG VGNC VGNC:73521
Canis familiaris HRG VGNC VGNC:41785
Felis catus HRG VGNC VGNC:67648
Bos taurus HRG VGNC VGNC:29953
Others HRG NCBI
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