1. Gene
  2. Dock1 - dedicator of cytokinesis 1 Gene

Dock1 - dedicator of cytokinesis 1 Gene

种属: Mus musculus

同用名: b2b3190Clo; 9130006G06Rik; D630004B07Rik

基因 ID: 330662 | 基因类型: protein coding

关于 Dock1

功能概要

Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Acts upstream of or within cell migration and hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Is expressed in endocardial cushion and midgut vascular element. Used to study DiGeorge syndrome and tetralogy of Fallot. Orthologous to human DOCK1 (dedicator of cytokinesis 1). [provided by Alliance of Genome Resources, Apr 2022]

Dock1 基因产物(1)

mRNA Protein Name
NM_001033420.2 NP_001028592.1 dedicator of cytokinesis protein 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15102471 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell migration IDA
IDA: 通过直接分析推断
15728191 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IGI
IGI: 通过遗传相互作用推断
24029230 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

dedicator of cytokinesis protein 1

180 kDa protein downstream of CRK

DOCK180

dedicator of cyto-kinesis 1

Dock1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Dock1 Q8BUR4 Elmo1 Mus musculus Q8BPU7-1
Y2H
15102471
种属内
Dock1 Q8BUR4 Elmo3 Mus musculus Q8BYZ7
Y2H
15102471
种属内
Dock1 Q8BUR4 Zhx2 Mus musculus Q8C0C0
Y2H
15102471
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dock1 NCBI NCBI:1793