2. Gene
  3. STING1 - stimulator of interferon response cGAMP interactor 1 Gene

STING1 - stimulator of interferon response cGAMP interactor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素反应刺激物 cGAMP 相互作用物 1

种属: Homo sapiens

同用名: ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta

基因 ID: 340061 | 基因类型: protein coding

关于 STING1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,475,533-139,482,758 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 184 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lung (RPKM 37.4), spleen (RPKM 28.8) and 24 other tissues.

功能概要

该基因编码一种五跨膜蛋白，作为对病毒和细菌感染的先天免疫反应的主要调节剂。编码的蛋白质是一种模式识别受体，可检测细胞溶质核酸并传递激活 I 型干扰素反应的信号。编码的蛋白质还显示通过与 II 型主要组织相容性复合体结合在细胞凋亡信号中发挥作用。该基因的突变是婴儿期发病的 STING 相关血管病变的原因。交替剪接导致多个转录本变体。[RefSeq 提供，2014 年 9 月]

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and Bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

STING1 基因产物(3)

mRNA Protein Name
NM_001301738.2 NP_001288667.1 stimulator of interferon genes protein isoform 2
NM_001367258.1 NP_001354187.1 stimulator of interferon genes protein isoform 3 precursor
NM_198282.4 NP_938023.1 stimulator of interferon genes protein isoform 1

STING1 蛋白结构

TMEM173

TMEM173: Transmembrane protein 173 (42 - 338)

  • 0
  • 100
  • 200
  • 300
  • 379 a.a.
蛋白主名 其他名称

stimulator of interferon genes protein

N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner

endoplasmic reticulum IFN stimulator

endoplasmic reticulum interferon stimulator

mitochondrial mediator of IRF3 activation

stimulator of interferon protein

transmembrane protein 173

重组 STING1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70700 TMEM173 Protein, Human (Sumo-His) Q86WV6 (V155-V341) ≥95%
HY-P70700A TMEM173 Protein, Human (N-Sumo-His) Q86WV6 (V155-V341) ≥95%

关联疾病

疾病名称 别名
Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous
Sting-Associated Vasculopathy, Infantile-Onset

SAVI

Autoinflammatory-Vasculopathy Syndrome
Vascular Skin Disease

Skin Diseases, Vascular

Skin Vascular Disease
Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung
Smallpox

Variola

Ordinary Smallpox

Alastrim

Amaas
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Autoimmune Disease Of Cardiovascular System
Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection
Sting-Associated Vasculopathy With Onset In Infancy

Savi

Sting-Associated Vasculopathy, Infantile Onset

Sting-Associated Vasculopathy, Infantile-Onset
Severe Covid-19
Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis

Niemann-Pick Diseases

Lipoid Histiocytosis

Sphingomyelin Lipidosis

Sphingomyelinase Deficiency Disease

Lipid Histiocytosis

Neuronal Cholesterol Lipidosis

Neuronal Lipidosis

Npd

Sphingomyelinase Deficiency

Niemann-Pick Disease, Type A
Familial Cold Autoinflammatory Syndrome 3

Plaid

Familial Atypical Cold Urticaria

Facu

FCAS3

Antibody Deficiency And Immune Dysregulation, Plcg2-Associated

Plcg2-Associated Antibody Deficiency And Immune Dysregulation

Familial Cold Urticaria With Common Variable Immunodeficiency

Plcg2 Associated Antibody Deficiency And Immune Dysregulation

Antibody Deficiency And Immune Dysregulation Placg2-Associated

Autoinflammatory Syndrome, Cold, Familial, Type 3
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Familial Chilblain Lupus
Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112906 C-176 Inhibitor 99.45% 否
HY-138683 STING-IN-3 Inhibitor 99.86% 否
HY-114399 STING ligand-1 99.79% 否
HY-12885C ADU-S100 enantiomer ammonium salt 98.82% 否
HY-148643 STING modulator-5 Modulator / 否
HY-RS13916 STING1 Human Pre-designed siRNA Set A / 否
HY-RS13917 Sting1 Mouse Pre-designed siRNA Set A / 否
HY-RS13918 Sting1 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STING1 VGNC VGNC:79674
Mus musculus STING1 MGD MGI:1919762
Canis familiaris STING1 VGNC VGNC:47498
Felis catus STING1 VGNC VGNC:66290
Rattus norvegicus STING1 RGD RGD:1562552
Bos taurus STING1 VGNC VGNC:35997
Others STING1 NCBI
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