ATP13A5 - ATPase 13A5 Gene

中文名称：ATP 酶 13A5

种属: Homo sapiens

关于 ATP13A5

功能概要

该基因编码 P 型转运 ATP 酶 P5 亚家族的成员。 P 型 ATP 酶形成一个大的阳离子泵和脂质泵超家族，可跨细胞膜运输无机阳离子和其他底物。 P5 ATPases 位于内质网 (ER) 的膜上，具有许多重要功能，包括将货物蛋白运输到高尔基体、糖基化和细胞壁生物合成、控制蛋白质插入方向、3-羟基-3-甲基戊二酰辅酶 A 还原酶 ( HMGR) 降解，以及对未折叠蛋白反应 (UPR) 激活剂的敏感性。编码的蛋白质分为三个细胞质结构域 (A、P 和 N) 和两个膜嵌入结构域 (T 和 S) 。 N 结构域结合 ATP 并充当内置蛋白激酶，磷酸化 P 结构域。 A 结构域是一种内在蛋白磷酸酶，它在每个催化循环期间使 P 结构域去磷酸化一次。[RefSeq 提供，2017 年 7 月]

This gene encodes a member of the P5 subfamily of P-type transport ATPases. P-type ATPases form a large superfamily of cation and lipid pumps that transport inorganic cations and Other substrates across cell membranes. P5 ATPases are localized to membranes of the endoplasmic reticulum (ER) and serve many important functions including transport of cargo proteins to the Golgi, glycosylation and cell wall biosynthesis, control of protein insertion orientation, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) degradation, and sensitivity to unfolded protein response (UPR) activators. The encoded protein is organized into three cytoplasmic domains (A, P, and N) and two membrane-embedded domains (T and S). The N-domain binds ATP and serves as a built-in protein kinase, which phosphorylates the P-domain. The A-domain is an intrinsic protein Phosphatase, which dephosphorylates the P-domain once during each catalytic cycle. [provided by RefSeq, Jul 2017]