IRGM - immunity related GTPase M Gene

中文名称：免疫相关 GTPase M

种属: Homo sapiens

同用名: IFI1; IRGM1; LRG47; LRG-47

基因 ID: 345611 | 基因类型: protein coding

关于 IRGM

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,846,521-150,902,402 (from NCBI)

This gene has 3 transcripts (splice variants), 360 orthologues, 1 paralogue and is associated with 3 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码 p47 免疫相关 GTPase 家族的成员。所编码的蛋白质可能通过调节响应细胞内病原体的自噬形成而在先天免疫反应中发挥作用。影响该基因正常表达的多态性与克罗恩病和肺结核的易感性有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 10 月]

This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating Autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]

IRGM 基因产物(2)

mRNA	Protein	Name
NM_001145805.2	NP_001139277.1	immunity-related GTPase family M protein isoform 2
NM_001346557.2	NP_001333486.1	immunity-related GTPase family M protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables BH3 domain binding	IMP IMP: 通过突变表型推断	25891078	GOA
enables CARD domain binding	IMP IMP: 通过突变表型推断	25891078	GOA
enables G protein activity	IDA IDA: 通过直接分析推断	30612879	GOA
enables GTPase activity	IDA IDA: 通过直接分析推断	29420192	GOA
enables cardiolipin binding	IDA IDA: 通过直接分析推断	21102437	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25891078	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	25891078	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: 通过直接分析推断	25891078	GOA
enables protein serine/threonine kinase activator activity	IMP IMP: 通过突变表型推断	28389568	GOA
enables protein-macromolecule adaptor activity	IDA IDA: 通过直接分析推断	25891078	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in CAMKK-AMPK signaling cascade	IMP IMP: 通过突变表型推断	25891078	GOA
involved in autophagosome assembly	IMP IMP: 通过突变表型推断	16888103	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: 通过突变表型推断	25891078	GOA
involved in cellular response to virus	IMP IMP: 通过突变表型推断	28389568	GOA
involved in defense response to Gram-negative bacterium	IMP IMP: 通过突变表型推断	25891078	GOA
involved in defense response to bacterium	IDA IDA: 通过直接分析推断	25891078	GOA
involved in defense response to bacterium	IMP IMP: 通过突变表型推断	16888103	GOA
involved in innate immune response	IMP IMP: 通过突变表型推断	16888103	GOA
involved in negative regulation of NLRP3 inflammasome complex assembly	IDA IDA: 通过直接分析推断	30612879	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: 通过直接分析推断	32715615	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	36221902	GOA
involved in negative regulation of defense response to virus	IDA IDA: 通过直接分析推断	34467632	GOA
involved in negative regulation of inflammatory response	IDA IDA: 通过直接分析推断	30612879	GOA
involved in negative regulation of type I interferon production	IDA IDA: 通过直接分析推断	32715615	GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: 通过突变表型推断	25891078	GOA
involved in positive regulation of autophagosome maturation	IMP IMP: 通过突变表型推断	16888103	GOA
involved in positive regulation of autophagy	IDA IDA: 通过直接分析推断	25891078	GOA
involved in positive regulation of autophagy	IMP IMP: 通过突变表型推断	16888103	GOA
involved in positive regulation of lysosome organization	IDA IDA: 通过直接分析推断	32753672	GOA
involved in positive regulation of mitochondrial fission	IDA IDA: 通过直接分析推断	21102437	GOA
involved in positive regulation of mitophagy	IDA IDA: 通过直接分析推断	21102437	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: 通过突变表型推断	25891078	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: 通过突变表型推断	25891078	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	28389568	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	28389568	GOA
involved in positive regulation of type II interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	16888103	GOA
involved in positive regulation of xenophagy	IDA IDA: 通过直接分析推断	25891078	GOA
involved in protein destabilization	IMP IMP: 通过突变表型推断	25891078	GOA
involved in protein lipidation involved in autophagosome assembly	IMP IMP: 通过突变表型推断	28389568	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	25891078	GOA
involved in protein targeting to vacuole involved in autophagy	IDA IDA: 通过直接分析推断	29420192	GOA
involved in protein-containing complex assembly	IDA IDA: 通过直接分析推断	25891078	GOA
involved in regulation of protein complex stability	IMP IMP: 通过突变表型推断	25891078	GOA
involved in regulation of protein-containing complex assembly	IMP IMP: 通过突变表型推断	25891078	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	28389568	GOA
located in Golgi membrane	IDA IDA: 通过直接分析推断	28389568	GOA
is active in autophagosome membrane	IDA IDA: 通过直接分析推断	30612879	GOA
located in cytosol	IDA IDA: 通过直接分析推断	25891078	GOA
is active in mitochondrion	IDA IDA: 通过直接分析推断	21102437	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	25891078	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRGM 蛋白结构

IIGP

0
100
181 a.a.

蛋白主名

其他名称

immunity-related GTPase family M protein

LPS-stimulated RAW 264.7 macrophage protein 47 homolog

IRGM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
种属内	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
种属内	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Inflammatory Bowel Disease 19

Inflammatory Bowel Disease 19	IBD19
Bowel Disease, Inflammatory, Type 19

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Colitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Inflammatory Bowel Disease 5

IBD5

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Crohn'S Colitis

Crohn Disease

Ileitis

Crohn'S Ileitis

Autoimmune Disease Of Gastrointestinal Tract

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06915	IRGM Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27268	Irgm Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	IRGM	RGD	RGD:1305163

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IRGM - immunity related GTPase M Gene

关于 IRGM

功能概要

IRGM 基因产物(2)

IRGM 蛋白结构

IRGM 蛋白互作信息

关联疾病

直系同源

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IRGM - immunity related GTPase M Gene

关于 IRGM

功能概要

IRGM 基因产物(2)

IRGM 蛋白结构

IRGM 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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