IL5RA - interleukin 5 receptor subunit alpha Gene

中文名称：白介素 5 受体亚基 α

种属: Homo sapiens

同用名: IL5R; CD125; CDw125; HSIL5R3

关于 IL5RA

功能概要

由该基因编码的蛋白质是异二聚体细胞因子受体的白细胞介素 5 特异性亚基。该受体由白细胞介素 3 (IL3) 、集落刺激因子 2 (CSF2/GM-CSF) 和白细胞介素 5 (IL5) 受体共享的配体特异性 α 亚基和信号转导 β 亚基组成。该蛋白与 IL5 的结合取决于 β 亚基。 β 亚基被配体结合激活，是 IL5 生物活性所必需的。已发现该蛋白质与 syndecan 结合蛋白 (syntenin) 相互作用，这是 IL5 介导的转录因子 SOX4 激活所必需的。已经报道了几种编码四种不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]