2. Gene
  3. Brca2 - BRCA2, DNA repair associated Gene

Brca2 - BRCA2, DNA repair associated Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 360254 | 基因类型: protein coding

关于 Brca2

功能概要

Enables single-stranded DNA binding activity. Involved in several processes, including homologous chromosome orientation involved in meiotic metaphase I plate congression; response to estradiol; and spermatogenesis. Predicted to be located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear lumen. Predicted to be part of BRCA2-MAGE-D1 complex. Predicted to be active in nucleus. Used to study atrophy of testis; cancer; cataract; infertility; and osteosarcoma. Biomarker of ductal carcinoma in situ and prostate Cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain Cancer (multiple); hereditary breast ovarian Cancer syndrome; melanoma (multiple); and reproductive organ Cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]

Brca2 基因产物(1)

mRNA Protein Name
NM_031542.2 NP_113730.2 breast cancer type 2 susceptibility protein homolog
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12228710 RGD
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
12228710 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA recombination IDA
IDA: 通过直接分析推断
12228710 RGD
involved in homologous chromosome orientation in meiotic metaphase I IMP
IMP: 通过突变表型推断
16964288 RGD
involved in mammary gland development IMP
IMP: 通过突变表型推断
16964288 RGD
involved in multicellular organism growth IMP
IMP: 通过突变表型推断
16964288 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
14583453 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
14583453 RGD
involved in spermatogenesis IMP
IMP: 通过突变表型推断
16964288 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

breast cancer type 2 susceptibility protein homolog

breast cancer 2, early onset

breast cancer 2, mutation 1, University of Wisconsin-Madison

breast cancer susceptibility protein 2

fanconi anemia group D1 protein homolog

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10617A Rucaparib Inhibitor 99.97% 否
HY-10617 Rucaparib phosphate Inhibitor 99.76% 是
HY-102003 Rucaparib (monocamsylate) Inhibitor 99.91% 是
HY-102003A Rucaparib camsylate Inhibitor / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-115552 Simmiparib Inhibitor 99.01% Phase 1
Pre-clinical Phase
生物活性分子 (24)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-124691 D-I03 Inhibitor 99.70% 否
HY-151462 RP-6685 Inhibitor 99.96% 否
HY-150147 CAM833 99.83% 否
HY-148183 Homologous recombination-IN-1 Inhibitor 98.65% 否
HY-122639 ZINC05007751 99.33% 否
HY-162706 BSJ-5-63 Degrader 99.97% 否
HY-40041 (R)-1-Boc-3-methyl-piperazine 99.86% 否
HY-170844 MU147 Inhibitor 99.35% 否
HY-161431 RTx-152 99.71% 否
HY-170845 MU1409 Inhibitor 98.52% 否
HY-RS01594 BRCA2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-122583 D-G23 Inhibitor / 否
HY-150958 RAD51-IN-8 / 否
HY-155766 PARP1-IN-14 / 否
HY-163816 Antiproliferative agent-53-d3 Inhibitor / 否
HY-168094 PARP1-IN-30 Inhibitor / 否
HY-168993 BRCA2-IN-2 Inhibitor / 否
HY-173151 BRCA2-IN-1 Inhibitor / 否
HY-173345 BRCA2-RAD51-IN-2 Inhibitor / 否
HY-177512 MSC778 Inhibitor / 否
HY-P10516 BRC4 peptide / 否
HY-162104 BRCA2-RAD51-IN-1 Inhibitor / 否
HY-RS16825 Brca2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23267 Brca2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Brca2 NCBI NCBI:675
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