2. Gene
  3. Ptprf - protein tyrosine phosphatase, receptor type, F Gene

Ptprf - protein tyrosine phosphatase, receptor type, F Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: LARFN5C

基因 ID: 360406 | 基因类型: protein coding

关于 Ptprf

功能概要

Enables phosphate ion binding activity; signaling receptor binding activity; and transmembrane receptor protein tyrosine Phosphatase activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of signal transduction; and regulation of cell projection organization. Located in several cellular components, including excitatory synapse; growth cone; and neuronal cell body. Is integral component of postsynaptic density membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine Phosphatase receptor type F). [provided by Alliance of Genome Resources, Apr 2022]

Ptprf 基因产物(1)

mRNA Protein Name
NM_019249.2 NP_062122.2 receptor-type tyrosine-protein phosphatase F precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables insulin receptor binding IDA
IDA: 通过直接分析推断
7711057 RGD
enables phosphate ion binding IDA
IDA: 通过直接分析推断
1918076 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12629171 RGD
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
8068021 RGD
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
16415345 RGD
enables transmembrane receptor protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
7711057 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: 通过直接分析推断
12716943 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16415345 RGD
involved in negative regulation of cell projection organization IMP
IMP: 通过突变表型推断
10699984 RGD
involved in negative regulation of cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
16415345 RGD
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
8557682 RGD
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
8557682 RGD
involved in negative regulation of neurotrophin TRK receptor signaling pathway IMP
IMP: 通过突变表型推断
10699984 RGD
involved in nervous system development IDA
IDA: 通过直接分析推断
12716943 RGD
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
9501065 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
15750591 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
10699984 RGD
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
7711057 RGD
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
15750591 RGD
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
15750591 RGD
involved in regulation of synapse structure or activity IMP
IMP: 通过突变表型推断
15750591 RGD
involved in synaptic membrane adhesion IDA
IDA: 通过直接分析推断
20139422 RGD
involved in synaptic membrane adhesion IMP
IMP: 通过突变表型推断
20139422 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
16269466 RGD
located in excitatory synapse IDA
IDA: 通过直接分析推断
15750591 RGD
located in growth cone IDA
IDA: 通过直接分析推断
9604206 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
9748473 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
15750591 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

receptor-type tyrosine-protein phosphatase F

LAR

leukocyte antigen-related (LAR) PTP receptor

leukocyte common antigen related

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11438 PTPRF Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17614 Ptprf Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24074 Ptprf Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptprf NCBI NCBI:5792
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