2. Gene
  3. IMPA2 - inositol monophosphatase 2 Gene

IMPA2 - inositol monophosphatase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌醇单磷酸酶 2

种属: Homo sapiens

基因 ID: 3613 | 基因类型: protein coding

关于 IMPA2

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:11,981,507-12,030,877 (from NCBI)

This gene has 12 transcripts (splice variants), 158 orthologues and 4 paralogues. Broad expression in kidney (RPKM 73.3), skin (RPKM 38.8) and 18 other tissues.

功能概要

该基因座编码肌醇单磷酸酶。编码的蛋白质催化肌醇单磷酸的去磷酸化，并在磷脂酰肌醇信号传导中起重要作用。该基因座可能与双相情感障碍的易感性有关。[RefSeq 提供，2011 年 1 月]

This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

IMPA2 基因产物(1)

mRNA Protein Name
NM_014214.3 NP_055029.1 inositol monophosphatase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables inositol monophosphate 1-phosphatase activity IDA
IDA: 通过直接分析推断
17068342 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
17068342 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to lithium ion IDA
IDA: 通过直接分析推断
15504365 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17068342 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IMPA2 蛋白结构

Inositol_P

Inositol_P: Inositol monophosphatase family (17 - 280)

  • 0
  • 100
  • 200
  • 288 a.a.
蛋白主名 其他名称

inositol monophosphatase 2

IMP 2

IMPA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IMPA2 O14732 SLC44A3 Homo sapiens Q8N4M1-3
Validated Y2H
32296183
种属内
IMPA2 O14732 IMPA1 Homo sapiens P29218-3
Y2H Prey Pooling
32296183
种属内
IMPA2 O14732 IMPA1 Homo sapiens P29218-3
Validated Y2H
32296183
种属内
IMPA2 O14732 IMPA1 Homo sapiens P29218-3
Y2H Array
32296183
种属内
IMPA2 O14732 UBA3 Homo sapiens Q8TBC4
Y2H Prey Pooling
32296183
种属内
IMPA2 O14732 UBA3 Homo sapiens Q8TBC4
Validated Y2H
25416956
种属内
IMPA2 O14732 UBA3 Homo sapiens Q8TBC4
Validated Y2H
32296183
种属内
IMPA2 O14732 UBA3 Homo sapiens Q8TBC4
Y2H Array
32296183
种属内
IMPA2 O14732 IMPA1 Homo sapiens P29218
Y2H Prey Pooling
25416956
种属内
IMPA2 O14732 IMPA1 Homo sapiens P29218
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IMPA2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70197 IMPA2 Protein, Human (His) O14732-1 (M1-K288) ≥95%

关联疾病

疾病名称 别名
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Febrile Seizures

Febrile Seizure

Febrile Convulsions

Seizures Febrile
Mood Disorder

Mood Disorders

Episodic Mood Disorder
Ring Dermoid Of Cornea

RDC

Ring Dermoid Syndrome

Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension

Dermoid Of Cornea, Ring
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Familial Febrile Seizures

Familial Febrile Convulsions

Feb

Febrile Seizures, Familial
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06796 IMPA2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20427 Impa2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26936 Impa2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IMPA2 RGD RGD:628692
Canis familiaris IMPA2 VGNC VGNC:49913
Mus musculus IMPA2 MGD MGI:2149728
Bos taurus IMPA2 VGNC VGNC:30185
Others IMPA2 NCBI
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