IMPA2 蛋白, Human (His)

IMPA2, or Inositol monophosphatase 2, demonstrates enzymatic activity by utilizing various substrates such as myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP. Additionally, it has been implicated as the pharmacological target for the action of lithium ions (Li⁺) in the brain. IMPA2 Protein, Human (His) is the recombinant human-derived IMPA2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IMPA2 Protein, Human (His) is 288 a.a., with molecular weight of ~30.0 kDa.

IMPA2 或肌醇单磷酸酶 2 是一种多功能酶，可以利用肌醇单磷酸、鲨肌醇 1,4-二磷酸、葡萄糖-1-磷酸、β-甘油磷酸和 2'-AMP 作为底物。这种酶的多样性表明在肌醇代谢和各种含肌醇分子的磷酸盐裂解中发挥作用。值得注意的是，IMPA2 被认为是锂 (Li+) 在大脑中作用的药理学靶点。与锂的关联表明其在调节细胞内肌醇水平方面具有潜在作用，强调了 IMPA2 在细胞过程中的重要性及其参与锂的治疗作用，锂是一种在精神治疗中广泛使用的情绪稳定剂。

Human

E. coli

N-6*His

O14732 (M1-K288)

3613  [NCBI]

MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHLVEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK

Approximately 30.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.