1. Gene
  2. Ncf2 - neutrophil cytosolic factor 2 Gene

Ncf2 - neutrophil cytosolic factor 2 Gene

种属: Rattus norvegicus

同用名: NCF-2

基因 ID: 364018 | 基因类型: protein coding

关于 Ncf2

功能概要

Predicted to enable protein C-terminus binding activity; small GTPase binding activity; and superoxide-generating NADPH Oxidase activator activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Located in cytoplasm and membrane. Used to study proteinuria; renal fibrosis; and visual epilepsy. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease cytochrome b-positive type II; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ncf2 基因产物(1)

mRNA Protein Name
NM_001395185.1 NP_001382114.1 neutrophil cytosol factor 2
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hormone stimulus IDA
IDA: 通过直接分析推断
18298462 RGD
involved in positive regulation of blood pressure IMP
IMP: 通过突变表型推断
19307699 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
18675340 RGD
involved in regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
27279484 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
17310390 RGD
involved in response to glucose IDA
IDA: 通过直接分析推断
19854265 RGD
involved in response to hyperoxia IEP
IEP: 通过表达模式推断
19337906 RGD
involved in response to laminar fluid shear stress IEP
IEP: 通过表达模式推断
19353375 RGD
involved in response to lipid IEP
IEP: 通过表达模式推断
19713964 RGD
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
17448908 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
19854265 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
19841131 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
17122189 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

neutrophil cytosol factor 2

neutrophil NADPH oxidase factor 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ncf2 NCBI NCBI:4688