1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. NADPH Oxidase

NADPH Oxidase (NADPH氧化酶)

NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The ROS generated by NADPH oxidases have crucial roles in various physiological processes, including innate immunity, modulation of redox-dependent signalling cascades, and as cofactors in the production of hormones.

NOX enzymes are a family of transmembrane proteins comprising seven members (NOX1-NOX5 and DUOX1 and DUOX2), each with a specific tissue distribution and activation mechanism. They catalyze the reduction of molecular oxygen to superoxide anion, which in turn reacts quickly to generate other ROS, such as hydrogen peroxide. Although basic NOX activity is crucial for normal physiology, overshooting activity of NOX enzymes leads to disease. NADPH oxidases are increasingly recognized as interesting drug targets.

NADPH Oxidase 相关产品 (13):

目录号 产品名 作用方式 纯度
  • HY-100965
    Diphenyleneiodonium chloride Inhibitor 99.90%
    Diphenyleneiodonium chloride 是一种 NADPH 氧化酶 (NOX) 抑制剂,也是一种 TRPA1 激活剂,EC50 值在 1 至 3 μM 之间。Diphenyleneiodonium chloride 选择性抑制胞内活性氧
  • HY-18950
    GSK2795039 Inhibitor 99.71%
    GSK2795039 是一种 NADPH 氧化酶 2 (NOX2) 抑制剂,在不同的无细胞试验中平均 pIC50 为 6。GSK2795039 抑制活性氧 (Reactive Oxygen Species) 产生和 NADPH 消耗,同时可减少细胞凋亡 (apoptosis)。
  • HY-12298
    Setanaxib Inhibitor ≥98.0%
    Setanaxib (GKT137831) 是选择性的NADPH氧化酶 (NOX1/4) 抑制剂,Ki 分别为140和110nM。
  • HY-12804
    VAS2870 Inhibitor 98.23%
    VAS2870是NADPH氧化酶 (NADPH oxidase (NOX)) 抑制剂。
  • HY-100111
    GLX351322 Inhibitor 99.94%
    GLX351322 是一种 NADPH 氧化酶 4 (Nox4) 抑制剂,在 NOX4 过表达的细胞中,抑制过氧化氢的产生,IC50 值为 5 μM。
  • HY-101499A
    GKT136901 hydrochloride Inhibitor 98.02%
    GKT136901 hydrochloride 是一种有效的,选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4 抑制剂,Ki 值分别为 160 和 165 nM。GKT136901 hydrochloride 也是一种选择性和直接的过氧亚硝酸清除剂。GKT136901 hydrochloride 可用于糖尿病肾病,中风和神经退行性疾病的研究。GKT136901 hydrochloride 还具有抗炎症活性。
  • HY-12805
    ML171 Inhibitor 99.90%
    ML171 (2-Acetylphenothiazine;2-APT) 是有效的选择性 NADPH 氧化酶 1 (Nox1) 抑制剂,可阻止 Nox-1 依赖性的 ROS 产生,在 HEK293-Nox1 验证试验中的 IC50 值为 0.25 μM。
  • HY-120801A
    APX-115 free base Inhibitor 99.47%
    APX-115 free base (Ewha-18278 free base) 是一种有效的,口服活性的,非选择性 Nox 抑制剂,对 Nox1Nox2Nox4Ki 值分别为 1.08 μM,0.57 μM 和 0.63 μM。APX-115 free base 可有效预防糖尿病小鼠的肾损伤。
  • HY-101499
    GKT136901 Inhibitor 99.12%
    GKT136901 是一种有效的,选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4 抑制剂,Ki 值分别为 160 和 165 nM。GKT136901 也是一种选择性和直接的过氧亚硝酸清除剂。GKT136901 可用于糖尿病肾病,中风和神经退行性疾病的研究。GKT136901 还具有抗炎症活性。
  • HY-120801
    APX-115 Inhibitor ≥98.0%
    APX-115 (Ewha-18278) 是一种有效的,口服活性的,非选择性 Nox 抑制剂,对 Nox1Nox2Nox4 的 Ki 值分别为 1.08 μM,0.57 μM 和 0.63 μM。APX-115 可有效预防糖尿病小鼠的肾损伤。
  • HY-P1435
    NoxA1ds Inhibitor
    NoxA1ds 是一种高效选择性 Nox1 (NADPH oxidase isoform 1) 抑制剂。NoxA1ds 为氧化酶激活所需的 Nox1-NOXA1 结合建立了一个关键的相互作用位点。NoxA1ds 可用于高血压、动脉粥样硬化和肿瘤的研究。
  • HY-P1435A
    NoxA1ds TFA Inhibitor
    NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
  • HY-12803
    Fulvene-5 Inhibitor
    Fulvene-5 是一种有效的 NADPH 氧化酶 4 (NOX4) 抑制剂,具有抗氧化特性。Fulvene-5 是一种活性氧 (ROS) 修饰剂和有效的辐射防护剂,并具有抗肿瘤活性。
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