2. Gene
  3. Aim2 - absent in melanoma 2 Gene

Aim2 - absent in melanoma 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gm1313; Ifi210

基因 ID: 383619 | 基因类型: protein coding

关于 Aim2

功能概要

Enables double-stranded DNA binding activity and identical protein binding activity. Involved in positive regulation of macromolecule metabolic process; pyroptosis; and regulation of defense response. Acts upstream of or within cellular response to interferon-beta. Located in cytoplasm. Part of AIM2 inflammasome complex. Orthologous to human AIM2 (absent in melanoma 2). [provided by Alliance of Genome Resources, Apr 2022]

Aim2 基因产物(1)

mRNA Protein Name
NM_001013779.2 NP_001013801.2 interferon-inducible protein AIM2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
19158679 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19158676 MGI
enables pattern recognition receptor activity IDA
IDA: 通过直接分析推断
23567559 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19158679 MGI
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
26197926 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in AIM2 inflammasome complex assembly IDA
IDA: 通过直接分析推断
23567559 MGI
involved in DNA damage response IDA
IDA: 通过直接分析推断
27846608 MGI
involved in T cell homeostasis IDA
IDA: 通过直接分析推断
33505023 MGI
involved in activation of innate immune response IDA
IDA: 通过直接分析推断
19158676 MGI
involved in brain development IDA
IDA: 通过直接分析推断
32350463 MGI
acts upstream of or within cellular response to interferon-beta IDA
IDA: 通过直接分析推断
19158679 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
26095253 MGI
involved in neuron cellular homeostasis IDA
IDA: 通过直接分析推断
32350463 MGI
involved in positive regulation of cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
19158676 MGI
involved in positive regulation of cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
19131592 MGI
involved in positive regulation of defense response to virus by host IMP
IMP: 通过突变表型推断
19158675 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
19158676 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IGI
IGI: 通过遗传相互作用推断
23997220 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
19158675 MGI
involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
19158676 MGI
involved in regulation of behavior IDA
IDA: 通过直接分析推断
32350463 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of AIM2 inflammasome complex IDA
IDA: 通过直接分析推断
19158679 MGI
is active in cytoplasm IDA
IDA: 通过直接分析推断
19158679 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
19158679 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
27846608 MGI
is active in site of double-strand break IDA
IDA: 通过直接分析推断
27846608 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interferon-inducible protein AIM2

ifi-210

interferon-inducible protein 210

interferon-inducible protein p210

Aim2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Aim2 Q91VJ1 Aim2 Mus musculus Q91VJ1
Crosslink
19158676
种属内
Aim2 Q91VJ1 Ralb Mus musculus Q9JIW9
Confocal
22286270
种属内
Aim2 Q91VJ1 Exoc8 Mus musculus Q6PGF7
Confocal
22286270
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0822 Shikonin Inhibitor 99.80% 否
HY-144226 NLRP3/AIM2-IN-3 Inhibitor 98.23% 否
HY-150751 ODN TTAGGG Antagonist 99.87% 否
HY-150751C ODN TTAGGG sodium Antagonist 93.80% 否
HY-152670 JC2-11 Inhibitor 98.03% 否
HY-144223 NLRP3/AIM2-IN-2 Inhibitor 99.93% 否
HY-138646 Poly(deoxyadenylic-thymidylic) acid sodium Activator / 否
HY-130480 Fructose-arginine Inhibitor 98.32% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aim2 NCBI NCBI:9447
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