2. Gene
  3. ARHGAP5 - Rho GTPase activating protein 5 Gene

ARHGAP5 - Rho GTPase activating protein 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 5

种属: Homo sapiens

同用名: GFI2; p190-B; RhoGAP5; p190BRhoGAP

基因 ID: 394 | 基因类型: protein coding

关于 ARHGAP5

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:32,075,880-32,159,728 (from NCBI)

This gene has 10 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 87 phenotypes. Ubiquitous expression in thyroid (RPKM 21.1), brain (RPKM 17.8) and 25 other tissues.

功能概要

Rho GTPase 激活蛋白 5 负向调节 RHO GTPases，该家族可能通过刺激结合的 GTP 的水解来介导细胞骨架的变化。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate Cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP5 基因产物(2)

mRNA Protein Name
NM_001030055.2 NP_001025226.1 rho GTPase-activating protein 5 isoform a
NM_001173.3 NP_001164.2 rho GTPase-activating protein 5 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH2 domain binding IPI
IPI: 通过物理相互作用推断
1689011 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23622247 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP5 蛋白结构

Ras

Ras: Ras family (155 - 246)

FF

FF: FF domain (485 - 545)

RhoGAP

RhoGAP: RhoGAP domain (1275 - 1423)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1502 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 5

growth factor independent 2

ARHGAP5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
ARHGAP5 Q13017 Rnd3 Mus musculus P61588
Anti Tag CoIP
23622247
种属间: 跨种属相互作用 种属内: 同种属相互作用

ARHGAP5 抗体

目录号 产品名 应用 反应物种
HY-P83074 RhoGAP Antibody (YA2819) WB, IHC-P, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00939 ARHGAP5 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ARHGAP5 VGNC VGNC:70008
Rattus norvegicus ARHGAP5 RGD RGD:1308507
Bos taurus ARHGAP5 VGNC VGNC:26098
Canis familiaris ARHGAP5 VGNC VGNC:38067
Felis catus ARHGAP5 VGNC VGNC:68119
Mus musculus ARHGAP5 MGD MGI:1332637
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