2. Gene
  3. Gjb2 - gap junction protein, beta 2 Gene

Gjb2 - gap junction protein, beta 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Cx26; Cxne; CXN-26

基因 ID: 394266 | 基因类型: protein coding

关于 Gjb2

功能概要

Enables gap junction channel activity. Involved in several processes, including cellular response to glucagon stimulus; reproductive structure development; and response to steroid hormone. Located in several cellular components, including astrocyte projection; gap junction; and lateral plasma membrane. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of autoimmune thyroiditis; extrahepatic cholestasis; ischemia; sensorineural hearing loss; and urethral obstruction. Human ortholog(s) of this gene implicated in Bart-Pumphrey syndrome; Vohwinkel syndrome; autosomal dominant keratitis-ichthyosis-deafness syndrome; nonsyndromic deafness (multiple); and palmoplantar keratoderma-deafness syndrome. Orthologous to human GJB2 (Gap Junction Protein beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Gjb2 基因产物(1)

mRNA Protein Name
NM_001004099.2 NP_001004099.1 gap junction beta-2 protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables gap junction channel activity IMP
IMP: 通过突变表型推断
23232329 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19864490 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
7593318 RGD
involved in cellular response to glucagon stimulus IEP
IEP: 通过表达模式推断
7593318 RGD
involved in cellular response to oxidative stress IEP
IEP: 通过表达模式推断
8631141 RGD
involved in decidualization IEP
IEP: 通过表达模式推断
1655436 RGD
involved in epididymis development IEP
IEP: 通过表达模式推断
12388089 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
8612484 RGD
involved in inner ear development IEP
IEP: 通过表达模式推断
10570462 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
10342836 RGD
involved in response to human chorionic gonadotropin IEP
IEP: 通过表达模式推断
9537254 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
24728265 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
10909894 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
8612484 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
9570757 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte projection IDA
IDA: 通过直接分析推断
11169992 RGD
located in cell body IDA
IDA: 通过直接分析推断
11169992 RGD
located in cell junction IDA
IDA: 通过直接分析推断
8770903 RGD
located in gap junction IDA
IDA: 通过直接分析推断
12064610 RGD
located in lateral plasma membrane IDA
IDA: 通过直接分析推断
12388089 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11738649 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gap junction beta-2 protein

connexin 26

connexin e

gap junction channel protein connexin 26

gap junction membrane channel protein beta 2

Gjb2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Gjb2 P21994 Cnst Mus musculus Q8CBC4-3
Pull Down
19864490
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05447 GJB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20742 Gjb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27254 Gjb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gjb2 NCBI NCBI:2706
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