2. Gene
  3. MEF2A - myocyte enhancer factor 2A Gene

MEF2A - myocyte enhancer factor 2A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌细胞增强因子 2A

种属: Homo sapiens

同用名: mef2; ADCAD1; RSRFC4; RSRFC9

基因 ID: 4205 | 基因类型: protein coding

关于 MEF2A

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:99,565,417-99,716,488 (from NCBI)

This gene has 18 transcripts (splice variants), 203 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 12.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种 DNA 结合转录因子，可激活许多肌肉特异性、生长因子诱导和应激诱导的基因。编码的蛋白质可以作为同源二聚体或异源二聚体，参与多种细胞过程，包括肌肉发育、神经元分化、细胞生长控制和细胞凋亡。该基因的缺陷可能是常染色体显性遗传性冠状动脉疾病 1 伴心肌梗死 (ADCAD1) 的原因。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2010 年 1 月]

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and Apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

MEF2A 基因产物(62)

mRNA Protein Name
NM_001130926.5 NP_001124398.1 myocyte-specific enhancer factor 2A isoform 2
NM_001130927.5 NP_001124399.1 myocyte-specific enhancer factor 2A isoform 3
NM_001130928.4 NP_001124400.1 myocyte-specific enhancer factor 2A isoform 4
NM_001171894.5 NP_001165365.1 myocyte-specific enhancer factor 2A isoform 2
NM_001319206.4 NP_001306135.1 myocyte-specific enhancer factor 2A isoform 5
NM_001352614.4 NP_001339543.1 myocyte-specific enhancer factor 2A isoform 2
NM_001352615.4 NP_001339544.1 myocyte-specific enhancer factor 2A isoform 2
NM_001352616.4 NP_001339545.1 myocyte-specific enhancer factor 2A isoform 5
NM_001352617.4 NP_001339546.1 myocyte-specific enhancer factor 2A isoform 1
NM_001352618.4 NP_001339547.1 myocyte-specific enhancer factor 2A isoform 6
NM_001365201.3 NP_001352130.1 myocyte-specific enhancer factor 2A isoform 7
NM_001365202.3 NP_001352131.1 myocyte-specific enhancer factor 2A isoform 7
NM_001365203.3 NP_001352132.1 myocyte-specific enhancer factor 2A isoform 8
NM_001365204.3 NP_001352133.1 myocyte-specific enhancer factor 2A isoform 8
NM_001365205.3 NP_001352134.1 myocyte-specific enhancer factor 2A isoform 5
NM_001365206.3 NP_001352135.1 myocyte-specific enhancer factor 2A isoform 6
NM_001365207.3 NP_001352136.1 myocyte-specific enhancer factor 2A isoform 1
NM_001365208.3 NP_001352137.1 myocyte-specific enhancer factor 2A isoform 2
NM_001365209.3 NP_001352138.1 myocyte-specific enhancer factor 2A isoform 3
NM_001365210.2 NP_001352139.1 myocyte-specific enhancer factor 2A isoform 10
NM_001365211.2 NP_001352140.1 myocyte-specific enhancer factor 2A isoform 11
NM_001393558.2 NP_001380487.1 myocyte-specific enhancer factor 2A isoform 12
NM_001393559.2 NP_001380488.1 myocyte-specific enhancer factor 2A isoform 4
NM_001393560.2 NP_001380489.1 myocyte-specific enhancer factor 2A isoform 13
NM_001393561.3 NP_001380490.1 myocyte-specific enhancer factor 2A isoform 14
NM_001400028.1 NP_001386957.1 myocyte-specific enhancer factor 2A isoform 15
NM_001400029.1 NP_001386958.1 myocyte-specific enhancer factor 2A isoform 8
NM_001400030.1 NP_001386959.1 myocyte-specific enhancer factor 2A isoform 8
NM_001400031.1 NP_001386960.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400032.1 NP_001386961.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400033.1 NP_001386962.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400034.1 NP_001386963.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400035.1 NP_001386964.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400036.1 NP_001386965.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400037.1 NP_001386966.1 myocyte-specific enhancer factor 2A isoform 6
NM_001400038.1 NP_001386967.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400039.1 NP_001386968.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400040.1 NP_001386969.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400049.1 NP_001386978.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400050.1 NP_001386979.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400051.1 NP_001386980.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400052.1 NP_001386981.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400053.1 NP_001386982.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400054.1 NP_001386983.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400055.1 NP_001386984.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400056.1 NP_001386985.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400057.1 NP_001386986.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400058.1 NP_001386987.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400059.1 NP_001386988.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400060.1 NP_001386989.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400061.1 NP_001386990.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400062.1 NP_001386991.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400063.1 NP_001386992.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400064.1 NP_001386993.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400065.1 NP_001386994.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400066.1 NP_001386995.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400067.1 NP_001386996.1 myocyte-specific enhancer factor 2A isoform 16
NM_001400068.1 NP_001386997.1 myocyte-specific enhancer factor 2A isoform 12
NM_001400069.1 NP_001386998.1 myocyte-specific enhancer factor 2A isoform 17
NM_001400070.1 NP_001386999.1 myocyte-specific enhancer factor 2A isoform 11
NM_001400071.1 NP_001387000.1 myocyte-specific enhancer factor 2A isoform 11
NM_005587.6 NP_005578.2 myocyte-specific enhancer factor 2A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
7760790 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
16043483 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10748098 GOA
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
20590529 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7760790 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20590529 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
15466416 GOA
enables SMAD binding IPI
IPI: 通过物理相互作用推断
11160896 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
21468593 GOA
enables histone acetyltransferase binding IPI
IPI: 通过物理相互作用推断
20590529 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
10748098 GOA
contributes to protein binding IPI
IPI: 通过物理相互作用推断
16043483 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7973707 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
9858528 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10835359 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated transcription IDA
IDA: 通过直接分析推断
16043483 GOA
involved in ERK5 cascade IMP
IMP: 通过突变表型推断
15132737 GOA
involved in MAPK cascade IDA
IDA: 通过直接分析推断
9858528 GOA
involved in cellular response to calcium ion IDA
IDA: 通过直接分析推断
16484498 GOA
involved in heart development IEP
IEP: 通过表达模式推断
10458488 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16484498 GOA
involved in positive regulation of cardiac muscle hypertrophy IDA
IDA: 通过直接分析推断
24161931 GOA
involved in positive regulation of cardiac muscle hypertrophy IGI
IGI: 通过遗传相互作用推断
24161931 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7760790 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
16484498 GOA
part of transcription regulator complex IDA
IDA: 通过直接分析推断
16043483 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MEF2A 蛋白结构

SRF-TF

SRF-TF: SRF-type transcription factor (DNA-binding and dimerisation domain) (10 - 59)

HJURP_C

HJURP_C: Holliday junction regulator protein family C-terminal repeat (90 - 154)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
蛋白主名 其他名称

myocyte-specific enhancer factor 2A

MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)

MEF2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MEF2A Q02078 PITX2 Homo sapiens Q99697-3
Pull Down
15466416
种属间
MEF2A Q02078 Nfix Mus musculus P70257-2
Anti Tag CoIP
20178747
种属间
MEF2A Q02078 Myod1 Mus musculus P10085
Pull Down
7973707
种属间: 跨种属相互作用 种属内: 同种属相互作用

MEF2A 抗体

目录号 产品名 应用 反应物种
HY-P83464 MEF2A Antibody (YA3209) WB, ICC/IF Human, Mouse, Rat
HY-P83579 MEF2A Antibody (YA3324) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Coronary Artery Disease, Autosomal Dominant, 1

ADCAD1

Coronary Artery Disease With Myocardial Infarction

Coronary Artery Disease/Myocardial Infarction

Artery, Coronary, Disease, Autosomal Dominant, Type 1
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Muscle Hypertrophy

MSLHP

Hypertrophy

Hypertrophy, Muscle
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Ichthyosis, Congenital, Autosomal Recessive 9

Autosomal Recessive Congenital Ichthyosis 9

ARCI9

Ichthyosis, Congenital, Autosomal Recessive, Type 9
Brachydactyly, Type E1

Brachydactyly Type E1

Brachydactyly Type E

BDE1

Brachydactyly, Type E

Bde

Type E Brachydactyly

Brachydactyly E1

Brachydactyly Syndrome Type E
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries
Rhabdomyosarcoma
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08309 MEF2A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19713 Mef2a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26209 Mef2a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MEF2A VGNC VGNC:31372
Mus musculus MEF2A MGD MGI:99532
Felis catus MEF2A VGNC VGNC:68229
Macaca mulatta MEF2A VGNC VGNC:74698
Rattus norvegicus MEF2A RGD RGD:1359360
Canis familiaris MEF2A VGNC VGNC:43143
Others MEF2A NCBI
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