MAP3K11 - mitogen-activated protein kinase kinase kinase 11 Gene

中文名称：有丝分裂原活化蛋白激酶激酶 11

种属: Homo sapiens

同用名: MLK3; PTK1; SPRK; MLK-3; MEKK11

关于 MAP3K11

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸激酶家族的成员。该激酶包含一个 SH3 结构域和一个亮氨酸拉链基序。该激酶优先激活 MAPK8/JNK 激酶，并作为 JNK 信号通路的正调节剂发挥作用。该激酶可直接磷酸化并激活 IkappaB 激酶 alpha 和 beta，被发现参与由 Rho 家族 GTP 酶和 CDC42 介导的 NF-kappaB 的转录活性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]