KLK14 - kallikrein related peptidase 14 Gene

中文名称：激肽释放酶相关肽酶 14

种属: Homo sapiens

同用名: KLK-L6

基因 ID: 43847 | 基因类型: protein coding

关于 KLK14

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,077,494-51,084,210 (from NCBI)

This gene has 3 transcripts (splice variants), 177 orthologues and 12 paralogues. Biased expression in skin (RPKM 2.1), testis (RPKM 0.2) and 6 other tissues.

功能概要

该基因编码丝氨酸蛋白酶激肽释放酶亚家族的一个成员，该亚家族具有调节血压和脱屑等多种生理功能。该基因表达的改变与包括乳腺癌和前列腺癌在内的不同癌症的进展有关。编码的蛋白质是一种前体，经过蛋白水解处理可产生功能性酶。该基因是位于 19 号染色体簇中的 15 个激肽释放酶亚家族成员之一。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 7 月]

This gene encodes a member of the Kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

KLK14 基因产物(3)

mRNA	Protein	Name
NM_001311182.2	NP_001298111.2	kallikrein-14 preproprotein
NM_001369775.2	NP_001356704.1	kallikrein-14 preproprotein
NM_022046.6	NP_071329.3	kallikrein-14 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables serine-type endopeptidase activity	IDA IDA: 通过直接分析推断	15654974	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epidermis morphogenesis	IDA IDA: 通过直接分析推断	17158887	GOA
involved in fertilization	IDA IDA: 通过直接分析推断	18482984	GOA
involved in negative regulation of G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	16885167	GOA
involved in positive regulation of G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	16885167	GOA
involved in proteolysis	IDA IDA: 通过直接分析推断	15654974	GOA
involved in seminal clot liquefaction	IDA IDA: 通过直接分析推断	18482984	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	15654974	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLK14 蛋白结构

Trypsin

0
100
200
267 a.a.

蛋白主名

其他名称

kallikrein-14

kallikrein-like protein 6

关联疾病

疾病名称

别名

Netherton Syndrome

NETH	Ns
Netherton Disease	Comel-Netherton Syndrome
Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige	Bamboo Hair Syndrome
Ichthyosis Linearis Circumflexa	Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige
Ilc	Nts
N Syndrome

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148949A	Kallikrein 5-IN-2 TFA	Inhibitor	99.53%	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	KLK14	VGNC	VGNC:42481
Mus musculus	KLK14	MGD	MGI:2447564
Rattus norvegicus	KLK14	RGD	RGD:1308606
Bos taurus	KLK14	VGNC	VGNC:30676
Others	KLK14	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KLK14 - kallikrein related peptidase 14 Gene

关于 KLK14

功能概要

KLK14 基因产物(3)

KLK14 蛋白结构

关联疾病

直系同源

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KLK14 - kallikrein related peptidase 14 Gene

关于 KLK14

功能概要

KLK14 基因产物(3)

KLK14 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z