NELL1 - neural EGFL like 1 Gene

中文名称：神经 EGFL 样 1

种属: Homo sapiens

同用名: NRP1; IDH3GL

基因 ID: 4745 | 基因类型: protein coding

关于 NELL1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:20,669,551-21,575,686 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 1 paralogue. Biased expression in brain (RPKM 7.1), kidney (RPKM 6.6) and 2 other tissues.

功能概要

该基因编码一种含有表皮生长因子 (EGF) 样重复序列的细胞质蛋白。编码的异源三聚体蛋白可能参与细胞生长调节和分化。啮齿类动物中的一种类似蛋白质与颅缝早闭有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 12 月]

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

NELL1 基因产物(4)

mRNA	Protein	Name
NM_001288713.1	NP_001275642.1	protein kinase C-binding protein NELL1 isoform 3 precursor
NM_001288714.1	NP_001275643.1	protein kinase C-binding protein NELL1 isoform 4 precursor
NM_006157.5	NP_006148.2	protein kinase C-binding protein NELL1 isoform 1 precursor
NM_201551.2	NP_963845.1	protein kinase C-binding protein NELL1 isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21723284	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of osteoblast proliferation	IDA IDA: 通过直接分析推断	21723284	GOA
involved in negative regulation of protein catabolic process	IDA IDA: 通过直接分析推断	21723284	GOA
involved in positive regulation of bone mineralization	IDA IDA: 通过直接分析推断	21723284	GOA
involved in positive regulation of osteoblast differentiation	IDA IDA: 通过直接分析推断	21723284	GOA
involved in regulation of gene expression	IDA IDA: 通过直接分析推断	21723284	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	21723284	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	21723284	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	21723284	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NELL1 蛋白结构

Laminin_G_2

VWC

EGF_CA

EGF_3

hEGF

EGF_CA

VWC

0
200
400
600
810 a.a.

蛋白主名

其他名称

protein kinase C-binding protein NELL1

nel-related protein 1

NELL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NELL1	Q92832	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	NELL1	Q92832	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	NELL1	Q92832	ATRAID	Homo sapiens	Q6UW56	IF	21723284
种属内	NELL1	Q92832	ATRAID	Homo sapiens	Q6UW56	Phage Display	21723284
种属内	NELL1	Q92832	ATRAID	Homo sapiens	Q6UW56	Anti Bait CoIP	21723284
种属内	NELL1	Q92832	ATRAID	Homo sapiens	Q6UW56	Pull Down	21723284

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Achard Syndrome

Arachnodactyly, Receding Lower Jaw And Joint Laxity Of Hands/Feet

Gnathodiaphyseal Dysplasia

GDD	Osteogenesis Imperfecta With Unusual Skeletal Lesions
Gnathodiaphyseal Sclerosis	Osteogenesis Imperfecta, Levin Type
Levin Syndrome 2	Dysplasia, Gnathodiaphyseal

Parietal Foramina

Enlarged Parietal Foramina	Hereditary Cranium Bifidum
Symmetric Parietal Foramina	Catlin Marks
Foramina Parietalia Permagna	Caitlin Marks
Cranium Bifidum	Cranium Bifidum Occultum
Fenestrae Parietals Symmetricae	Fpp
Giant Parietal Foramina	Pfm
Fenestrae Parietales Symmetricae	Foramina, Parietal

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Cleidocranial Dysplasia

Cleidocranial Dysostosis	CLCD
Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only	Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly
CCD	Marie-Sainton Disease
Dysplasia Cleidocranial	Dento-Osseous Dysplasia
Marie-Sainton Syndrome	Dysplasia, Cleidocranial

Synostosis

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09204	NELL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20453	Nell1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26962	Nell1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NELL1	RGD	RGD:620998
Canis familiaris	NELL1	VGNC	VGNC:43739
Macaca mulatta	NELL1	VGNC	VGNC:75312
Mus musculus	NELL1	MGD	MGI:2443902
Felis catus	NELL1	VGNC	VGNC:81973

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NELL1 - neural EGFL like 1 Gene

关于 NELL1

功能概要

NELL1 基因产物(4)

NELL1 蛋白结构

NELL1 蛋白互作信息

关联疾病

直系同源

热门区域

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NELL1 - neural EGFL like 1 Gene

关于 NELL1

功能概要

NELL1 基因产物(4)

NELL1 蛋白结构

NELL1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z