2. Gene
  3. ACR - acrosin Gene

ACR - acrosin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：顶体蛋白

种属: Homo sapiens

基因 ID: 49 | 基因类型: protein coding

关于 ACR

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,738,204-50,745,339 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 105 orthologues. Restricted expression toward testis (RPKM 44.8).

功能概要

顶体蛋白是存在于成熟精子顶体中的主要蛋白酶。它是一种典型的丝氨酸蛋白酶，具有类胰蛋白酶的特异性。它以其前体形式 proacrosin 储存在顶体中。活性酶在透明带裂解中发挥作用，从而促进精子穿透卵子最内层的糖蛋白层。 proacrosin 的 mRNA 仅在精子发生的减数分裂后阶段合成。在人类中，proacrosin 首先出现在单倍体精子细胞中。[RefSeq 提供，2008 年 7 月]

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

ACR 基因产物(1)

mRNA Protein Name
NM_001097.3 NP_001088.2 acrosin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-mannose binding IDA
IDA: 通过直接分析推断
15950652 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7521127 GOA
enables serine-type endopeptidase activity IDA
IDA: 通过直接分析推断
6802470 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acrosome reaction IMP
IMP: 通过突变表型推断
2550339 GOA
involved in activation of adenylate cyclase activity IDA
IDA: 通过直接分析推断
3880736 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
7521127 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACR 蛋白结构

Trypsin

Trypsin: Trypsin (43 - 285)

  • 0
  • 100
  • 200
  • 300
  • 421 a.a.
蛋白主名 其他名称

acrosin

acrosin light and heavy chain prepropeptide

关联疾病

疾病名称 别名
Varicocele

Scrotal Varices

Varicoceles

Varicocele Of Scrotum

Scrotal Varicocele
Spermatogenic Failure 6

Globozoospermia

SPGF6

Round-Headed Spermatozoa

Acrosome Malformation Of Spermatozoa

Spermatogenic Failure 9

Spermatozoa, Round-Headed

Globozoospermia, Complete

Globozoospermia, Total

Mae Infertility Due To Round-Headed Spermatozoa

Male Infertility Due To Globozoospermia

Male Infertility Due To Round-Headed Spermatozoa

Round-Headed Sperm Syndrome

Spgf9

Teratozoospermia
Chronic Congestive Splenomegaly
Pulmonary Coin Lesion

Coin Lesion Of Lung

Solitary Pulmonary Nodule

Coin Lesion Lung
Rectum Lymphoma

Lymphoma Of Rectum
Supine Hypotensive Syndrome

Maternal Hypotension Syndrome

Antepartum Maternal Hypotension Syndrome

Postpartum Maternal Hypotension Syndrome

Maternal Hypotension Syndrome, Antepartum Condition Or Complication

Maternal Hypotension Syndrome, Postpartum Condition Or Complication

Maternal Hypotension Syndrome, Unspecified Trimester
Nutmeg Liver

Chronic Passive Congestion Of Liver
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Infertility
Waterhouse-Friderichsen Syndrome

Fatal Pneumococcal Waterhouse-Friderichsen Syndrome

Meningococcal Hemorrhagic Adrenalitis

Waterhouse-Friderichsen Syndrome, Meningococcal

Meningococcal Haemorrhagic Adrenalitis

Meningococcal Adrenal Syndrome

Acute Adrenal Insufficiency With Meningococcal Septicaemia

Adrenal Haemorrhage Syndrome

Waterhouse-Friderichsen Disease

Meningococcal Waterhouse-Friderichsen Syndrome

Haemorrhagic Meningococcal Adrenitis
Mucocele Of Salivary Gland

Ranula

Salivary Cyst

Salivary Gland Mucocele

Mucous Retention Cyst Of Salivary Gland

Retention Cyst Of Salivary Gland

Sialocele

Cyst Of Salivary Gland Or Duct

Extravasation Cyst Of Salivary Gland
Colonic Lymphangioma

Lymphangioma Of Colon

Colon Lymphangioma
Sialolithiasis

Sialolith

Stone Of Salivary Gland Or Duct

Salivary Gland Calculi

Salivary Gland Stone

Calculus Of Salivary Gland Or Duct

Calculus Of Salivary Gland

Salivary Calculus

Salivary Gland Calculus

Salivary Stone

Salivary Duct Calculi

Sialodocholithiasis
Parasitic Ichthyosporea Infectious Disease
Rhinosporidiosis

Infection By Rhinosporidium Seeberi

Rhinosporosis
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein
Acquired Hemangioma
Mucinous Adenofibroma
Schizophrenia 14

Sczd14

Schizophrenia, Susceptibility To, 14

Schizophrenia Susceptibility Locus, Chromosome 2q32-Related
Urinary Bladder Small Cell Neuroendocrine Carcinoma

Small Cell Neuroendocrine Carcinoma Of The Urinary Bladder

Small Cell/Neuroendocrine Carcinoma Of Urinary Bladder
Lemierre'S Syndrome

Lemierre Syndrome

Lemierre Postanginal Sepsis

Necrobacillosis

Postanginal Sepsis Secondary To Orophyngeal Infection

Septic Phlebitis Of The Internal Jugular Vein

Fusobacterium Infections

Acute Sore Throat

Human Necrobacillosis

Postanginal Sepsis

Oropharyngeal Infection Leading To Secondary Septic Thrombophlebitis Of The Internal Jugular Vein
Chronic Dacryocystitis
Oligoasthenoteratozoospermia

Oat

Oligoasthenoteratospermia
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-10684 Pridopidine Antagonist 99.85% Phase 3
HY-19845 Ordopidine Antagonist / Phase 1
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-129126 NC9 Inhibitor 99.98% 否
HY-RS00193 ACR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-111210 Pridopidine hydrochloride Antagonist / 否
HY-RS17573 Acr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24033 Acr Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-19845A Ordopidine hydrochloride Modulator / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ACR VGNC VGNC:69386
Felis catus ACR VGNC VGNC:59529
Rattus norvegicus ACR RGD RGD:2024
Bos taurus ACR VGNC VGNC:25557
Mus musculus ACR MGD MGI:87884
Canis familiaris ACR VGNC VGNC:37526
Macaca fascicularis ACR NCBI NCBI:102115325
Others ACR NCBI
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